2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. DPQ

DPQ 是一种具有血脑屏障透过性和选择性的 PARP-1 抑制剂，可阻断 PARP-1 介导的 DNA 损伤修复及 NAD+/ATP 消耗，从而抑制过度炎症反应。DPQ 抑制 NF-κB 通路激活、减少促炎因子 (如 TNF-α、IL-6) 表达及氧化应激。DPQ 可用于急性肺损伤、心肌梗死及神经退行性疾病的炎症相关研究。

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DPQ Chemical Structure

DPQ Chemical Structure

CAS No. : 129075-73-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1996
In-stock
1 mg ￥760
In-stock
5 mg ￥3000
In-stock
10 mg ￥4500
In-stock
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Customer Review

Other Forms of DPQ:

DPQ 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DPQ is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases[1][2][3].

IC50 & Target

PARP-1

 

体外研究
(In Vitro)

DPQ (10 μM；预处理 30 min，处理 2-8 h) 显著抑制 LPS (100 ng/mL) 刺激的小鼠腹腔巨噬细胞中 TNF-α、IL-1β、IL-6、CXCL-1、MIP-2 和 iNOS 的 mRNA 表达[2]。

DPQ (10 μM；预处理 30 min，处理 2-8 h) 抑制 LPS (100 ng/mL) 诱导的巨噬细胞中 IkB-α 降解及 NF-κB p65 磷酸化，阻断炎症信号通路[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DPQ 相关抗体:

Apoptosis Analysis[1]

Cell Line: Mixed murine cortical neurons
Concentration: 10 μM
Incubation Time: 10 min pretreatment + 20 min NMDA exposure
Result: Reduced NMDA-induced neuronal apoptosis by 84% at 6 h and 50% at 24 h, restored ATP levels from 4% to 72% of control, and suppressed PARP activation.

Real Time qPCR[2]

Cell Line: Murine peritoneal macrophages
Concentration: 10 μM
Incubation Time: 30 min pretreatment + 2-8 h LPS stimulation
Result: Significantly decreased LPS-induced mRNA expression of TNF-α (50% reduction), IL-1β (40%), IL-6 (45%), CXCL-1 (35%), MIP-2 (40%), and iNOS (50%).

Western Blot Analysis[2]

Cell Line: Murine peritoneal macrophages
Concentration: 10 μM
Incubation Time: 30 min pretreatment + 15-60 min LPS stimulation
Result: Blocked LPS-induced IkB-α degradation (50% inhibition at 15 min) and NF-κB p65 phosphorylation (40% reduction at 30 min).

Immunofluorescence[2][3]

Cell Line: Murine peritoneal macrophages
Concentration: 10 μM
Incubation Time: 30 min pretreatment + 1 h LPS stimulation
Result: Reduced LPS-induced PARP activation (40% decrease in PAR fluorescence intensity) and nitrotyrosine formation (35% reduction).
体内研究
(In Vivo)

DPQ (10 mg/kg；腹腔注射；单次；6 小时) 在 LPS 诱导的 C57BL/6 小鼠急性肺损伤模型中显著减轻肺炎症、中性粒细胞浸润及血管渗漏，抑制 NF-κB 通路激活[2]。
DPQ (10 mg/kg；腹腔注射；单次；4 周) 在 Wistar 大鼠心肌梗死模型中改善心脏功能，减少细胞凋亡及氧化应激损伤[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-Induced Acute Lung Injury Model in C57BL/6 mice (male, 8-10 weeks old)
Dosage: 10 μg/kg (dissolved in 0.01% DMSO (PBS)
Administration: Intraperitoneal injection, 30 min after LPS chanllenge (7.5 mg/kg; ip; single dose)
Result: Reduced neutrophil infiltration (50% decrease), MPO activity (40% decrease), and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in lungs.
Restored vascular permeability (Evans blue extravasation reduced by 35%), and inhibited apoptotic cell death (TUNEL-positive cells decreased by 45%).
Suppressed NF-κB activation with reduced IkB-α degradation and p65 phosphorylation.
Animal Model: Myocardial Infarction model in Wistar rats (male, 4 months old) via coronary artery ligation[3]
Dosage: 10 mg/kg (dissolved in DMSO)
Administration: Intraperitoneal injection, single dose immediately after MI induction
Result: Improved cardiac function (FS increased by 25%, EDD/ESD reduced by 15%), decreased apoptotic cardiomyocytes (TUNEL-positive cells reduced by 40%), and suppressed cleaved caspase-3 and PARP1 expression. Oxidative stress markers (O2-, nitrotyrosine) were reduced by 30-40% in infarcted myocardium.
分子量

302.41

Formula

C18H26N2O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (330.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3068 mL 16.5338 mL 33.0677 mL
5 mM 0.6614 mL 3.3068 mL 6.6135 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.68%

COA (283 KB) HNMR (123 KB) LCMS (104 KB)

产品使用指南 (1538 KB)
参考文献

DPQ 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3068 mL 16.5338 mL 33.0677 mL 82.6692 mL
5 mM 0.6614 mL 3.3068 mL 6.6135 mL 16.5338 mL
10 mM 0.3307 mL 1.6534 mL 3.3068 mL 8.2669 mL
15 mM 0.2205 mL 1.1023 mL 2.2045 mL 5.5113 mL
20 mM 0.1653 mL 0.8267 mL 1.6534 mL 4.1335 mL
25 mM 0.1323 mL 0.6614 mL 1.3227 mL 3.3068 mL
30 mM 0.1102 mL 0.5511 mL 1.1023 mL 2.7556 mL
40 mM 0.0827 mL 0.4133 mL 0.8267 mL 2.0667 mL
50 mM 0.0661 mL 0.3307 mL 0.6614 mL 1.6534 mL
60 mM 0.0551 mL 0.2756 mL 0.5511 mL 1.3778 mL
80 mM 0.0413 mL 0.2067 mL 0.4133 mL 1.0334 mL
100 mM 0.0331 mL 0.1653 mL 0.3307 mL 0.8267 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPQ129075-73-6PARPpoly ADP ribose polymeraseNeuroprotectionNeuronal injuryNMDAATPInhibitorinhibitorinhibit

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