2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. Mineralocorticoid Receptor Carbonic Anhydrase
  4. DSR-71167

DSR-71167 是一种口服有效的盐皮质激素受体 (MR) 拮抗剂，其 IC50 为 0.26 μM。DSR-71167 具有微弱的碳酸酐酶 (CA) 抑制活性，IC50 为 19 μM。DSR-71167 在大鼠模型中能剂量依赖性地增加尿钠排泄，在钾负荷大鼠模型中具有极低的高钾血症风险。DSR-71167 在高血压大鼠模型中降低收缩压。DSR-71167 可用于研究高血压和心衰。

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DSR-71167

DSR-71167 Chemical Structure

CAS No. : 1355687-91-0

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DSR-71167 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure[1].

分子量

529.96

Formula

C23H23ClF3N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DSR-71167 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSR-711671355687-91-0DSR71167DSR 71167Mineralocorticoid ReceptorCarbonic AnhydraseCarbonate dehydratasemineralocorticoid receptor antagonistcarbonic anhydrase inhibitorhyperkalemiahypertensionheart failuresafety profiledual mechanismurinary sodium excretionInhibitorinhibitorinhibit

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