2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Elotuzumab

Elotuzumab  (Synonyms: 埃罗妥珠单抗; HuLuc 63; PDL 063; BMS 901608)

目录号: HY-P9965 纯度: 98.58%
COA 技术支持

Elotuzumab (HuLuc 63) 是一种靶向 SLAMF7 受体的 IgG1 单克隆抗体。Elotuzumab 可通过激活自然杀伤细胞及诱导抗体依赖性细胞介导的细胞毒性发挥抗肿瘤活性。Elotuzumab 可与 Lenalidomide (HY-A0003)、Dexamethasone (HY-14648) 等联合用于多发性骨髓瘤等肿瘤的研究。

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CAS No. : 915296-00-3

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Elotuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

SLAMF7/CS1
体外研究
(In Vitro)

Elotuzumab (0.1-10 μg/mL; 4-20 h) 在人 PBMC 与 OPM-2 细胞共培养体系中上调 NK 细胞 CD107a、CD69、CD54 表达，并促进 IFN-γ 和 TNF-α 分泌[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Elotuzumab 相关抗体:
体内研究
(In Vivo)

Elotuzumab (10 mg/kg; 腹腔注射; 3 次; 每 3-4 天 1 次) 在表达 hSLAMF7 的小鼠肿瘤模型中具有抗肿瘤的活性，与抗 PD-1 抗体连用效果更好[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice treated A20-hSLAMF7 cells or EG7-hSLAMF7 cells[2]
Dosage: 10 mg/kg (Elotuzumab in the form of murine IgG2a subtype)
Administration: Intraperitoneal injection; 3 times; once every 3-4 days
Result: Inhibited tumor growth, increased tumor-infiltrating NK cells and CD8+ T cells, and the expression of activation markers on these cells.
Promoted tumor-infiltrating NK and CD81 T-cell activation, as well as increased intratumoral cytokine and chemokine release by combination with anti-PD-1 antibody.
Clinical Trial
基因 ID

57823  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.44 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

埃罗妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human CS1 can bind Elotuzumab. The EC50 for this effect is 20.87 ng/mL.
纯度 & 产品资料

纯度: 98.58%

COA (267 KB) SDS-PAGE (59 KB) SEC-HPLC (97 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Elotuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elotuzumab915296-00-3HuLuc 63 PDL 063 BMS 901608埃罗妥珠单抗HuLuc63HuLuc-63PDL063PDL 063PDL-063BMS901608BMS 901608BMS-901608Transmembrane Glycoproteinmonoclonal antibodySLAMF7antimyeloma activityRRMMInhibitorinhibitorinhibit

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