2. PI3K/Akt/mTOR Immunology/Inflammation Anti-infection
  3. PI3K Akt Interleukin Related Bacterial
  4. FHND5032

FHND5032 是一种具有口服活性的 miR-124 诱导剂。FHND5032 显著上调巨噬细胞中 miR-124 的表达。FHND5032 通过抑制 PIK3R2/PI3K/Akt 轴，阻断炎症信号，促进巨噬细胞重编程，并恢复上皮屏障功能。FHND5032 缓解溃疡性结肠炎小鼠的结肠炎并降低炎症负荷。FHND5032 可用于溃疡性结肠炎的研究。

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FHND5032

FHND5032 Chemical Structure

CAS No. : 3076057-63-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥748
In-stock
5 mg ￥680
In-stock
10 mg ￥1088
In-stock
25 mg ￥2176
In-stock
50 mg ￥3485
In-stock
100 mg ￥5525
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

FHND5032 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FHND5032 is an orally active miR-124 inducer. FHND5032 significantly upregulates miR-124 expression in macrophages. FHND5032 disrupts inflammatory signaling, promotes macrophage reprogramming, and restores the epithelial barrier function by inhibiting the PIK3R2/PI3K/Akt axis. FHND5032 alleviates colitis and reduces inflammatory burden in ulcerative colitis mice. FHND5032 can be used for the study of ulcerative colitis[1].

体外研究
(In Vitro)

FHND5032 (0-20 μM, 24 h) 通过增强 miR-124 表达，在 THP-1 和 RAW 264.7 细胞中显著发挥抗炎活性[1]。
FHND5032 (≤ 5 μM) 通过靶向 PIK3R2 激活 miR-124-5p 表达，调控 THP-1 和 RAW 264.7 细胞重编程中的 PI3K/Akt 通路[1]。
FHND5032 降低 RAW 264.7 中 M1 标记物 CD86 的表达，同时增加 M2 标记物 CD206 的表达[1]。
FHND5032 促进 Caco-2 细胞中屏障密封蛋白 ZO-1 和 occludin 的表达，以增强紧密连接 (TJ) 组装[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FHND5032 相关抗体:

Real Time qPCR[1]

Cell Line: THP-1 and RAW 264.7 cells
Concentration: 5, 10 μM
Incubation Time: /
Result: Upregulated miR-124 levels and induced miR-124 expression, which peaked at a concentration of 5 μM.
Decreased TNF-α, IL-1β, and IL-6 expression in LPS (HY-D1056)- and IFN-γ-stimulated THP-1 cells and LPS stimulated RAW 264.7 cells.
Decreased the expression of PIK3R2
体内研究
(In Vivo)

FHND5032 (25-50 mg/kg，灌胃，每日一次，持续 12 天) 在 Dextran sulfate sodium salt (DSS) (HY-116282C) 诱导的溃疡性结肠炎小鼠模型中缓解结肠炎并降低炎症负荷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS-induced female C57BL/6J mice (18-20 g)[1]
Dosage: 25, 50 mg/kg
Administration: i.g. once daily for 12 days
Result: Restrained the body weight loss of DSS-induced colitis mice.
Reduced the hematochezia occurrence during treatment.
Showed longer colon length of mice.
Protected the colonic barrier from pathological damage.
Decreased the local level of UC-associated myeloperoxidase (MPO) in the colon.
Reduced the expression of pro-inflammatory cytokines, including IL-6, TNF-α, and IFN-γ.
Increased the expression of anti-inflammatory cytokines IL-10.
Prevented intestinal damage in UC through elevation of TJ proteins.
Prevented the FITC-dextran leakage.
Inhibited colonic inflammation and repaired the intestinal barrier in colitis mice.
Upregulated the miR-124 expression and decreased PIK3R2 expression.
Attenuated PIK3R2 upregulation and the hyperphosphorylation of PI3K and Akt.
Showed no significant discrepancies in serum physicochemical parameters (alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine (Cr)).
Decreased the abundance of Proteobacteria in colitis mice and effectively enhanced the relative abundance of Firmicutes.
Showed no increase on the abundance of Bacteroidota.
分子量

339.70

Formula

C15H9ClF3N3O
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (147.19 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9438 mL 14.7189 mL 29.4377 mL
5 mM 0.5888 mL 2.9438 mL 5.8875 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

FHND5032 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9438 mL 14.7189 mL 29.4377 mL 73.5943 mL
5 mM 0.5888 mL 2.9438 mL 5.8875 mL 14.7189 mL
10 mM 0.2944 mL 1.4719 mL 2.9438 mL 7.3594 mL
15 mM 0.1963 mL 0.9813 mL 1.9625 mL 4.9063 mL
20 mM 0.1472 mL 0.7359 mL 1.4719 mL 3.6797 mL
25 mM 0.1178 mL 0.5888 mL 1.1775 mL 2.9438 mL
30 mM 0.0981 mL 0.4906 mL 0.9813 mL 2.4531 mL
40 mM 0.0736 mL 0.3680 mL 0.7359 mL 1.8399 mL
50 mM 0.0589 mL 0.2944 mL 0.5888 mL 1.4719 mL
60 mM 0.0491 mL 0.2453 mL 0.4906 mL 1.2266 mL
80 mM 0.0368 mL 0.1840 mL 0.3680 mL 0.9199 mL
100 mM 0.0294 mL 0.1472 mL 0.2944 mL 0.7359 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FHND50323076057-63-8FHND 5032FHND-5032PI3KAktInterleukin RelatedBacterialPhosphoinositide 3-kinasePKBProtein kinase BILmiR-124ulcerative colitis,THP-1 cellsRAW 264.7 cellsInhibitorinhibitorinhibit

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目录号：
HY-174976
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