2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Topoisomerase Antibiotic
  4. Gatifloxacin hydrochloride

Gatifloxacin hydrochloride  (Synonyms: 加替沙星盐酸盐; AM-1155 hydrochloride; BMS-206584 hydrochloride; PD135432 hydrochloride)

目录号: HY-10581A 纯度: 99.89%
COA 产品使用指南

摩尔计算器

Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种有效的氟喹诺酮类抗生素 (antibiotic)，具有广谱抗菌活性。Gatifloxacin hydrochloride (AM-1155 hydrochloride) 可抑制细菌 II 型拓扑异构酶 (type II topoisomerases) (IC50=13.8 μg/ml; 金黄色葡萄球菌拓扑异构酶 IV) 和大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)。Gatifloxacin hydrochloride (AM-1155 hydrochloride) 在动物模型中，可用于细菌性结膜炎的研究。

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Gatifloxacin hydrochloride Chemical Structure

Gatifloxacin hydrochloride Chemical Structure

CAS No. : 121577-32-0

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥440
In-stock
500 mg ￥400
In-stock
1 g ￥500
In-stock
5 g ￥980
In-stock
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50 g   询价  

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Customer Review

Other Forms of Gatifloxacin hydrochloride:

Gatifloxacin hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

IC50 & Target[1]

Quinolone

 

Topoisomerase II

36.7 μM ()

体外研究
(In Vitro)

Gatifloxacin hydrochloride is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with IC50 values of 13.8 μg/ml, 0.109 μg/ml, and 265 μg/ml, respectively[1].
Gatifloxacin hydrochloride is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with MIC values of 0.05 μg/ml, 0.0063 μg/ml, and 122 μg/ml, respectively[1].
Gatifloxacin hydrochloride exhibits antibacterial activities for wild-type strains (MS5935, MS5952, MR5867 and MR6009) the first-, second-, third-, and fourth-step mutants with MIC values of 0.05 to 0.10 μg/ml, 0.20 μg/ml, 1.56 to 3.13 μg/ml, 1.56 to 6.25 μg/ml, and 50 to 200 μg/ml, respectively. Gatifloxacin hydrochloride displays the most potent activity against the second- and third-step mutants (MS5952, MR5867 and MR6009) except for the second-step mutant of strain MS5935[2].
Gatifloxacin hydrochloride has potent activity against norA transformant NY12 (MIC, 0.39 μg/ml)[2].
Gatifloxacin hydrochloride (20-100 μM; 72 hours) significantly decreases insulin content to 60% at Day 1, and continues to be reduced to 50.1% and 44.7% at Day 3 by 20 μM and 100 μM Gatifloxacin hydrochloride, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gatifloxacin hydrochloride 相关抗体:
体内研究
(In Vivo)

Gatifloxacin hydrochloride (subcutaneous injection; 100 mg/kg; 3 times a day; 30 days) significantly decreases the number of lesions in mouse footpad with Nocardia brasiliensis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice with Nocardia brasiliensis in the right hind footpad[1]
Dosage: 100 mg/kg
Administration: Subcutaneous injection; 3 times a day; 30 days
Result: Reduced the production of lesions in mice.
Clinical Trial
分子量

411.86

Formula

C19H23ClFN3O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

加替沙星盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 10 mg/mL (24.28 mM; 超声助溶)

DMSO 中的溶解度 : 4 mg/mL (9.71 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4280 mL 12.1400 mL 24.2801 mL
5 mM 0.4856 mL 2.4280 mL 4.8560 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 6.67 mg/mL (16.19 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.94%

COA (266 KB) HNMR (272 KB) LCMS (267 KB)

产品使用指南 (1538 KB)
参考文献

Gatifloxacin hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.4280 mL 12.1400 mL 24.2801 mL 60.7002 mL
5 mM 0.4856 mL 2.4280 mL 4.8560 mL 12.1400 mL
H2O 10 mM 0.2428 mL 1.2140 mL 2.4280 mL 6.0700 mL
15 mM 0.1619 mL 0.8093 mL 1.6187 mL 4.0467 mL
20 mM 0.1214 mL 0.6070 mL 1.2140 mL 3.0350 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gatifloxacin121577-32-0AM-1155BMS-206584PD135432加替沙星盐酸盐AM1155AM 1155BMS206584BMS 206584PD 135432PD-135432BacterialTopoisomeraseAntibioticE. coli,?Pseudomonas aeruginosa,?Micrococcus luteusS. aureushypoglycemiahyperglycemiadiabeticactinomycetomaN. brasiliensisbacterialconjunctivitisInhibitorinhibitorinhibit

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目录号：
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