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  2. Xiap - X-linked inhibitor of apoptosis Gene

Xiap - X-linked inhibitor of apoptosis Gene

中文名称:X 连锁细胞凋亡抑制因子

种属: Mus musculus

同用名: Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 1110015C02Rik

基因 ID: 11798 | 基因类型: protein coding

关于 Xiap

Chromosome X: 41,148,556-41,198,533 forward strand.GRCm39:CM001013.3

This gene has 11 transcripts (splice variants), 217 orthologues, 10 paralogues and is associated with 15 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 7.1), bladder adult (RPKM 6.9) and 26 other tissues.

功能概要

由该基因编码的蛋白质是细胞凋亡抑制剂 (IAP) 蛋白质家族的成员。虽然首先发现它在阻断细胞凋亡中的作用,但这种蛋白质调节许多其他信号过程,包括活化 B 细胞 (NF-kB) 通路的核因子 kappa-轻链增强子和炎症反应。这种蛋白质通过在目标半胱天冬酶被激活后结合和抑制它们来阻断细胞凋亡。一些(但不是全部)半胱天冬酶会发生结合。这种蛋白质有几个保守区域,包括杆状病毒 IAP 重复 (BIR) 基序和环指 E3 连接酶结构域。在人类中,该基因的突变与 X 连锁淋巴组织增生综合征 2 型 (XLP-2) 的免疫缺陷有关。在 7 号染色体上发现了该基因的假基因。可变剪接导致多个转录本变体。 [RefSeq 提供,2014 年 8 月]

The protein encoded by this gene is a member of the inhibitor of Apoptosis (IAP) family of proteins. While first identified for its role in blocking Apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks Apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Xiap 基因产物(3)

mRNA Protein Name
NM_001301641.1 NP_001288570.1 E3 ubiquitin-protein ligase XIAP
NM_001301639.1 NP_001288568.1 E3 ubiquitin-protein ligase XIAP
NM_009688.3 NP_033818.2 E3 ubiquitin-protein ligase XIAP

Xiap 蛋白结构

BIR

BIR: cd00022 (27 - 94)

BIR

BIR: smart00238 (161 - 231)

BIR

BIR: smart00238 (263 - 329)

UBA_BIRC4_8

UBA_BIRC4_8: cd14395 (368 - 417)

RING-HC_BIRC4_8

RING-HC_BIRC4_8: cd16714 (432 - 495)

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  • 496 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase XIAP

IAP homolog A

RING-type E3 ubiquitin transferase XIAP

X-linked IAP

baculoviral IAP repeat-containing protein 4

inhibitor of apoptosis protein 3

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Xiap NCBI NCBI:331