2. Gene
  3. Cdk6 - cyclin-dependent kinase 6 Gene

Cdk6 - cyclin-dependent kinase 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 6

种属: Mus musculus

同用名: Crk2

基因 ID: 12571 | 基因类型: protein coding

关于 Cdk6

Chromosome 5: 3,391,485-3,581,008 forward strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 199 orthologues, 25 paralogues and is associated with 48 phenotypes. Ubiquitous expression in thymus adult (RPKM 7.), lung adult (RPKM 3.6) and 26 other tissues.

功能概要

该基因编码细胞周期蛋白依赖性激酶蛋白家族的成员，该蛋白在细胞周期的进程和调节中起着重要作用。编码的蛋白质与 D 型细胞周期蛋白结合形成活性激酶复合物，以调节细胞周期 G1 期的进程。缺乏编码蛋白的小鼠表现出胸腺和脾脏发育不全，以及造血缺陷，例如巨核细胞和红细胞数量减少。该基因的假基因已在 4 号染色体上定义。[RefSeq 提供，2015 年 8 月]

This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]

Cdk6 基因产物(1)

mRNA Protein Name
NM_009873.3 NP_034003.1 cyclin-dependent kinase 6

Cdk6 蛋白结构

STKc_CDK6

STKc_CDK6: cd07862 (10 - 299)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 6

CR2 protein kinase

cell division protein kinase 6

serine/threonine-protein kinase PLSTIRE

相关产品

Approval
生物活性分子 (13)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50767 Palbociclib Inhibitor 99.94% 否
HY-16297A Abemaciclib Inhibitor 99.96% 是
HY-15777 Ribociclib Inhibitor 99.98% 否
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% 否
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
HY-A0065 Palbociclib isethionate Inhibitor 99.99% 否
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% 否
HY-50767C Palbociclib hydrochloride Inhibitor 99.84% 否
HY-15777B Ribociclib succinate Inhibitor 99.93% 否
HY-101467A Trilaciclib hydrochloride Inhibitor 99.74% 否
HY-15777C Ribociclib succinate hydrate Inhibitor 99.96% 否
HY-50767D Palbociclib orotate Inhibitor / 否
HY-50767B Palbociclib dihydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (19)
目录号 产品名 作用方式
纯度 Phase
HY-114338A Dalpiciclib hydrochloride Inhibitor 99.92% Phase 3
HY-114338 Dalpiciclib Inhibitor 99.40% Phase 3
HY-101563 GSK3326595 99.97% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-12624 Narazaciclib Inhibitor 99.12% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-16559 Riviciclib hydrochloride 99.01% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-111361 FN-1501 Inhibitor 99.08% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.87% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
生物活性分子 (62)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103248 Toyocamycin Inhibitor 99.90% 否
HY-139450 PF-07220060 Inhibitor 99.87% 否
HY-10329 JNJ-7706621 Inhibitor 99.91% 否
HY-111556 BSJ-03-123 Inhibitor 98.12% 否
HY-136250 BSJ-03-204 Inhibitor 99.76% 否
HY-136252 BSJ-04-132 Inhibitor 98.32% 否
HY-114177 Ebvaciclib Inhibitor 99.98% 否
HY-10014 R547 Inhibitor 99.57% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.80% 否
HY-138946 XY028-140 Inhibitor 98.42% 否
HY-12445 Asnuciclib Inhibitor 99.76% 否
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.94% 否
HY-116035 Nimbolide Inhibitor 99.94% 否
HY-125835 CP-10 Inhibitor 98.22% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-129336 Abemaciclib metabolite M20 Inhibitor 96.02% 否
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.01% 否
HY-129180 XY028-133 Inhibitor 98.62% 否
HY-148530 YX-2-107 Degrader 99.79% 否
HY-50767S Palbociclib-d8 Inhibitor 99.84% 否
HY-15889 AMG 925 Inhibitor 98.20% 否
HY-148062 RSS0680 98.03% 否
HY-15241 NVP-LCQ195 Inhibitor 98.91% 否
HY-112243A Cimpuciclib tosylate Inhibitor 99.16% 否
HY-148063 DB0614 98.80% 否
HY-126251 CDK9-IN-7 Inhibitor 98.05% 否
HY-114339 CDK4/6-IN-2 Inhibitor 99.82% 否
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% 否
HY-142076 CDK4/6-IN-15 Inhibitor 96.15% 否
HY-15889A AMG 925 HCl Inhibitor / 否
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 97.01% 否
HY-112346 RGB-286147 Inhibitor 98.60% 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-136726 CGP-82996 Inhibitor / 否
HY-112243 Cimpuciclib Inhibitor / 否
HY-126244 CDK4/6-IN-3 Inhibitor / 否
HY-103712 Samuraciclib Inhibitor / 否
HY-131063 CDK6/9-IN-1 Inhibitor / 否
HY-143257 CDK4/6-IN-7 Inhibitor / 否
HY-115942 Anticancer agent 29 Inhibitor / 否
HY-148214 CDK2/4/6-IN-2 Inhibitor / 否
HY-153336 CDK-IN-12 Inhibitor / 否
HY-162529 CDK4/6-IN-19 Inhibitor / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor / 否
HY-153088 CDK4/6-IN-16 Inhibitor / 否
HY-162530 CDK4/6-IN-20 Inhibitor / 否
HY-112418 CDK4/6-IN-18 Inhibitor / 否
HY-126534 Abemaciclib metabolite M18 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-143258 CDK4/6-IN-8 Inhibitor / 否
HY-147409 Ulecaciclib Inhibitor / 否
HY-163787 YY173 Inhibitor / 否
HY-163786 PROTAC CDK4/6 degrader 1 Degrader / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-148213 CDK2/4/6-IN-1 Inhibitor / 否
HY-162619 CDK9-IN-33 Inhibitor / 否
HY-155787 SHR5428 Inhibitor / 否
HY-115993 CDK4/6-IN-10 Inhibitor / 否
HY-115992 CDK4/6-IN-9 Inhibitor / 否
HY-146213 CDK4/6-IN-12 Inhibitor / 否
HY-151898 CDK4/6-IN-14 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk6 NCBI NCBI:1021
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