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  2. Cx3cr1 - chemokine (C-X3-C motif) receptor 1 Gene

Cx3cr1 - chemokine (C-X3-C motif) receptor 1 Gene

中文名称:趋化因子 (C-X3-C 基序) 受体 1

种属: Mus musculus

同用名: mCX3CR1

基因 ID: 13051 | 基因类型: protein coding

关于 Cx3cr1

Chromosome 9: 119,730,682-119,898,945 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 259 orthologues, 25 paralogues and is associated with 50 phenotypes. Ubiquitous expression in cortex adult (RPKM 8.3), frontal lobe adult (RPKM 7.) and 27 other tissues.


该基因编码的蛋白可启动 C-X3-C 趋化因子结合活性和 C-X3-C 趋化因子受体活性。参与多个过程,包括白细胞迁移;神经系统发育;和突触组织。作用于多个过程的上游或内部,包括巨噬细胞趋化性;参与免疫反应的小胶质细胞激活;在配体不存在的情况下外在凋亡信号通路的负调节。位于细胞表面。以多种结构表达,包括冒号;泌尿生殖系统;和肝脏。用于研究年龄相关性黄斑变性 12。该基因的人类直系同源物涉及多种疾病,包括人类免疫缺陷病毒传染病;肥胖;肺动脉高压;视网膜疾病(多发);和系统性硬皮病。与人 CX3CR1(C-X3-C 基序趋化因子受体 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables C-X3-C chemokine binding activity and C-X3-C Chemokine Receptor activity. Involved in several processes, including leukocyte migration; nervous system development; and synapse organization. Acts upstream of or within several processes, including macrophage chemotaxis; microglial cell activation involved in immune response; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cell surface. Is expressed in several structures, including colon; genitourinary system; and liver. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cx3cr1 基因产物(1)

mRNA Protein Name
NM_009987.4 NP_034117.3 CX3C chemokine receptor 1

Cx3cr1 蛋白结构


7tmA_CX3CR1: cd15186 (32 - 59)


7tmA_CX3CR1: cd15186 (32 - 304)


7tmA_CX3CR1: cd15186 (66 - 91)


7tmA_CX3CR1: cd15186 (102 - 132)


7tmA_CX3CR1: cd15186 (144 - 166)


7tmA_CX3CR1: cd15186 (188 - 216)


7tmA_CX3CR1: cd15186 (224 - 254)


7tmA_CX3CR1: cd15186 (272 - 297)

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  • 300
  • 354 a.a.
蛋白主名 其他名称

CX3C chemokine receptor 1

C-X3-C CKR-1

chemokine (C-X3-C) receptor 1

fractalkine receptor


种属 基因名 来源 基因 ID
Homo sapiens Cx3cr1 NCBI NCBI:1524