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  2. Dnmt1 - DNA methyltransferase (cytosine-5) 1 Gene

Dnmt1 - DNA methyltransferase (cytosine-5) 1 Gene

中文名称:DNA 甲基转移酶 (cytosine-5) 1

种属: Mus musculus

同用名: Dnmt; MCMT; Met1; Cxxc9; MTase; Met-1; Dnmt1o; m.MmuI; MommeD2

基因 ID: 13433 | 基因类型: protein coding

关于 Dnmt1

Chromosome 9: 20,818,505-20,871,184 reverse strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 21 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 37.3), thymus adult (RPKM 36.6) and 27 other tissues.


该基因编码的甲基转移酶优先甲基化半甲基化 DNA 中 CpG 残基的胞嘧啶,从而在 DNA 复制过程中产生完全甲基化的 CpG 碱基对。这种酶在多种细胞过程中发挥作用,包括细胞周期调节、DNA 修复和端粒维持。编码的蛋白质由一个具有核定位序列和复制叉靶向结构域的 N 末端结构域、一个 DNA 结合 CXXC 结构域、两个溴代相邻同源结构域和一个 C 末端催化结构域组成。该基因的小鼠胚胎干细胞突变体是可行的,但当引入种系时,会导致隐性致死表型,突变体胚胎显示发育迟缓和发育缺陷。可变剪接导致多个转录本变体。 [RefSeq 提供,2015 年 9 月]

This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This Enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Dnmt1 基因产物(6)

mRNA Protein Name
NM_001199431.2 NP_001186360.2 DNA (cytosine-5)-methyltransferase 1 isoform 1
NM_001199432.2 NP_001186361.1 DNA (cytosine-5)-methyltransferase 1 isoform 3
NM_001314011.2 NP_001300940.1 DNA (cytosine-5)-methyltransferase 1 isoform 5
NM_001199433.2 NP_001186362.1 DNA (cytosine-5)-methyltransferase 1 isoform 4
NM_001404685.2 NP_001391614.2 DNA (cytosine-5)-methyltransferase 1 isoform 6
NM_010066.5 NP_034196.5 DNA (cytosine-5)-methyltransferase 1 isoform 2

Dnmt1 蛋白结构


DMAP_binding: pfam06464 (15 - 105)


PRK12678: cl36163 (116 - 294)


DNMT1-RFD: pfam12047 (404 - 539)


zf-CXXC: pfam02008 (647 - 693)


BAH_Dnmt1_I: cd04760 (757 - 880)


BAH_Dnmt1_II: cd04711 (968 - 1103)


Dcm: COG0270 (1140 - 1593)

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  • 1620 a.a.
蛋白主名 其他名称

DNA (cytosine-5)-methyltransferase 1

DNA MTase MmuI

DNA methyltransferase MmuI


种属 基因名 来源 基因 ID
Homo sapiens Dnmt1 NCBI NCBI:1786