2. Gene
  3. CPB2 - carboxypeptidase B2 Gene

CPB2 - carboxypeptidase B2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 B2

种属: Homo sapiens

同用名: CPU; PCPB; TAFI

基因 ID: 1361 | 基因类型: protein coding

关于 CPB2

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:46,053,186-46,105,033 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 8 paralogues. Restricted expression toward liver (RPKM 288.0).

功能概要

羧肽酶是水解 C 末端肽键的酶。羧肽酶家族包括金属、丝氨酸和半胱氨酸羧肽酶。根据它们的底物特异性，这些酶被称为羧肽酶 A (切割脂肪族残基) 或羧肽酶 B (切割碱性氨基残基) 。由该基因编码的蛋白质被胰蛋白酶激活并作用于羧肽酶 B 底物。凝血酶激活后，成熟蛋白下调纤维蛋白溶解。已经描述了该基因及其启动子区域的多态性。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 6 月]

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The Carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as Carboxypeptidase A (cleaving aliphatic residues) or Carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on Carboxypeptidase B substrates. After Thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

CPB2 基因产物(2)

mRNA Protein Name
NM_001278541.2 NP_001265470.1 carboxypeptidase B2 isoform 2 preproprotein
NM_001872.5 NP_001863.3 carboxypeptidase B2 isoform 1 preproprotein

CPB2 蛋白结构

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (32 - 105)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (129 - 410)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
蛋白主名 其他名称

carboxypeptidase B2

carboxypeptidase B-like protein

重组 CPB2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7735 Carboxypeptidase B2/CPB2 Protein, Human (HEK293, His) Q96IY4 (F23-V423) ≥95%
HY-P75451 Carboxypeptidase B2/CPB2 Protein, Human (423a.a, HEK293, His) Q96IY4 (M1-V423) ≥95%

关联疾病

疾病名称 别名
Factor Xiii Deficiency

Hereditary Factor Xiii Deficiency Disease

Deficiency, Laki-Lorand Factor

Congenital Factor Xiii Deficiency

Fibrin Stabilizing Factor Deficiency

Deficiency, Factor Xiii

Factor Xiii Deficiency Disease

Deficiency Of Factor Xiii

Fibrin-Stabilizing Factor Deficiency

Factor Xiii Deficiency, Congenital
Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency

Rosenthal Syndrome

Pta Deficiency

Hemophilia C

Rosenthal Factor Deficiency

F11 Deficiency

Congenital Factor Xi Deficiency

Hereditary Factor Xi Deficiency Disease

Haemophilia C

Factor Xi Deficiency, Autosomal Dominant

Rosenthal'S Disease

Factor 11 Deficiency

Factor Xi

Factor Xi Deficiency, Autosomal Recessive

Factor Xi Deficiency, Congenital

FA11D

Thromboplastin Antecedent Deficiency

Pta - [Plasma Thromboplastin Antecedent] Deficiency

Congenital Factor Xi Deficiency Disease

Rosenthal Disease
Hemophilia B

Christmas Disease

Factor Ix Deficiency

F9 Deficiency

HEMB

Plasma Thromboplastin Component Deficiency

Congenital Factor Ix Deficiency

Mild Hemophilia B

Severe Hemophilia B

Congenital Factor Ix Disorder

Deficiency, Functional Factor Ix

Hem B

Mild Congenital F9 Deficiency

Mild Congenital Factor Ix Deficiency

Moderate Hemophilia B

Moderate Congenital F9 Deficiency

Moderate Congenital Factor Ix Deficiency

Severe Congenital F9 Deficiency

Severe Congenital Factor Ix Deficiency

Bleeding Disorder In Hemophilia B Carriers

Congenital F9 Deficiency

Recessive X-Linked Hemophilia B
Thrombosis

Thrombosis Of Blood Vessel
Pulmonary Embolism

Pulmonary Artery Embolism

Pulmonary Embolus

Pulmonary Emboli
Disseminated Intravascular Coagulation

Defibrination Syndrome

Dic

Diffuse Or Disseminated Intravascular Coagulation

Fibrinolytic Purpura

Consumption Coagulopathy

Diffuse Intravascular Coagulation

Dic - [Disseminated Intravascular Coagulation]

Disseminated Intravascular Coagulopathy

Fibrinolysis Nos

Thrombolytic Purpura
Thrombophilia

Hypercoagulability State
Coronary Stenosis

Coronary Artery Stenosis
Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome

Hughes Syndrome

Familial Antiphospholipid Syndrome

Aps

Lupus Anticoagulant, Familial

Anti-Phospholipid Syndrome

Apls

Classic Apls

Classic Antiphospholipid Syndrome

Acromegaloid Facial Appearance Syndrome

Anticardiolipin Syndrome
Prostate Signet Ring Cell Adenocarcinoma

Prostate Signet Ring Cell Carcinoma

Signet Ring Cell Carcinoma Of Prostate

Acinar Prostate Adenocarcinoma, Signet Ring Variant
Gas Gangrene

Myonecrosis

Gas Bacillus Infection

Gas Gangrene Due To Clostridia

Clostridial Myonecrosis

Clostridial Cellulitis
Byssinosis

Flax-Dressers' Disease

Cotton Mill Fever

Stripper'S Asthma

Monday Morning Fever

Cotton Workers' Lung Disease

Cotton-Dust Asthma

Mill Fever

Lung Fibrosis With Byssinosis

Airway Disease Due To Cotton Dust

Respiratory Tract Disorder Due To Cotton Dust

Strippers' Disease

Flax-Dressers' Disorder

Strippers' Asthma
Post-Thrombotic Syndrome

Postphlebitic Syndrome

Postthrombotic Syndrome

Postphlebetic Syndrome With Inflammation

Postphlebetic Syndrome With Ulcer

Postphlebetic Syndrome With Ulcer And Inflammation

Venous Stress Disorder
Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Budd-Chiari Syndrome

Hepatic Vein Thrombosis

Chiari Syndrome

BDCHS

Membranous Obstruction Of The Inferior Vena Cava

Budd-Chiari Syndrome, Somatic

Movc

Budd-Chiari Syndrome, Susceptibility To, Somatic

Budd-Chiari Syndrome, Susceptibility To

Membranous Obstruction Of Inferior Vena Cava

Hepatic Vein Block

Obstruction Of Hepatic Veins

Hepatic Vein Obstruction

Hepatic Venous Block
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

Atypical Hemolytic Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To

Ahus

AHUS1

Hemolytic-Uremic Syndrome

Ahus 1

Ahus, Susceptibility To, 1

Hemolytic Uremic Syndrome, Atypical

Non-Shiga-Like Toxin-Associated Hus

Non-Stx-Hus

Nonenteropathic Hus

Atypical Hus

Shiga Toxin-Associated Hemolytic Uremic Syndrome

D+ Hus

Ehec-Hus

Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

Hemolytic Uremic Syndrome With Diarrhea

Stec-Hus

Shiga-Like Toxin-Associated Hus

Stx-Hus

Typical Hus

Typical Hemolytic Uremic Syndrome

Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

Atypical Hus With Anti-Factor H Antibodies

Ahus With Anti-Factor H Antibodies

Ahus With Neutralizing Autoantibodies Against Factor H

Hemolytic Uremic Syndrome Atypical 1

Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

D Hus

Hemolytic-Uremic Syndrome Without Diarrhea

Hemolytic-Uremic Syndrome, Atypical, Type 1

Hemolytic Uremic Syndrome, Typical
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03088 CPB2 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CPB2 MGD MGI:1891837
Bos taurus CPB2 VGNC VGNC:27646
Macaca mulatta CPB2 VGNC VGNC:71457
Canis familiaris CPB2 VGNC VGNC:39550
Felis catus CPB2 VGNC VGNC:61118
Rattus norvegicus CPB2 RGD RGD:71035
Others CPB2 NCBI
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