Igf1r - insulin-like growth factor I receptor Gene

中文名称：胰岛素样生长因子 I 受体

种属: Mus musculus

同用名: hyft; CD221; IGF-1R; D930020L01; A330103N21Rik

关于 Igf1r

功能概要

该基因编码的蛋白可启动胰岛素样生长因子结合活性。参与多个过程，包括肾上腺发育；冷诱导产热的正调节；和减数分裂细胞周期的正调控。作用于多个过程的上游或内部，包括腺体发育；肽基酪氨酸自磷酸化；和细胞内信号转导的调节。位于 T 管。是膜的组成部分。以多种结构表达，包括消化系统；脑;泌尿生殖系统；肢;和肺。该基因的人类直系同源物与多种疾病有关，包括痴呆症（多种）；肾癌（多发性）；肝病（多发性）；神经系统癌症（多发性）；和神经退行性疾病（多种）。与人类 IGF1R（胰岛素样生长因子 1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development; positive regulation of cold-induced thermogenesis; and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney Cancer (multiple); liver disease (multiple); nervous system Cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (Insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]