1. Protein Tyrosine Kinase/RTK
  2. PDGFR
    VEGFR
  3. SU4312

SU4312 

目录号: HY-100349 纯度: 98.19%
产品使用指南

SU4312 是 (Z)-SU4312 和 (E)-SU4312 的外消旋体。(Z)-SU4312 抑制 PDGFR 和 FLK-1,IC50 分别为 19.4 和 0.8 μM。(E)-SU4312 抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R,IC50 分别为 24.2,5.2,18.5,16.9 和 10.0 μM。

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SU4312 Chemical Structure

SU4312 Chemical Structure

CAS No. : 5812-07-7

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Description

SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1].

IC50 & Target[1]

PDGFR

 

Flk-1

 

In Vitro

Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers[1].

Molecular Weight

264.32

Formula

C₁₇H₁₆N₂O

CAS No.

5812-07-7

SMILES

O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SU4312SU 4312SU-4312PDGFRVEGFRPlatelet-derived growth factor receptorVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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产品名称:
SU4312
目录号:
HY-100349
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