2. Gene
  3. Dot1l - DOT1-like, histone H3 methyltransferase (S. cerevisiae) Gene

Dot1l - DOT1-like, histone H3 methyltransferase (S. cerevisiae) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：DOT1 样组蛋白 H3 甲基转移酶 (酿酒酵母)

种属: Mus musculus

同用名: Dot1; KMT4; mDot1; A630076O07

基因 ID: 208266 | 基因类型: protein coding

关于 Dot1l

Chromosome 10: 80,591,040-80,631,295 forward strand.GRCm39:CM001003.3

This gene has 7 transcripts (splice variants), 205 orthologues and is associated with 18 phenotypes. Ubiquitous expression in testis adult (RPKM 34.5), adrenal adult (RPKM 27.1) and 28 other tissues.

功能概要

该基因编码的蛋白可启动组蛋白甲基转移酶活性。在上游或内部对基因表达产生负面影响。位于细胞质和细胞核中。以多种结构表达，包括第 1 鳃弓；血液;心;感觉器官；和卵黄囊。用于研究扩张型心肌病 1A。该基因的人类直系同源物与混合表型急性白血病有关。与人 DOT1L 同源（DOT1 像组蛋白赖氨酸甲基转移酶）。 [由基因组资源联盟提供，2022 年 4 月]

Enables Histone Methyltransferase activity. Acts upstream of or within with a negative effect on gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; blood; heart; sensory organ; and yolk sac. Used to study dilated cardiomyopathy 1A. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dot1l 基因产物(1)

mRNA Protein Name
NM_199322.2 NP_955354.1 histone-lysine N-methyltransferase, H3 lysine-79 specific

Dot1l 蛋白结构

DOT1

DOT1: pfam08123 (114 - 316)

CC_DOT1L

CC_DOT1L: cd20902 (480 - 544)

Mplasa_alph_rch

Mplasa_alph_rch: cl37461 (509 - 658)

PHA03307

PHA03307: cl33723 (780 - 1124)

Herpes_BLLF1

Herpes_BLLF1: cl37540 (941 - 1313)

  • 0
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  • 1540 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase, H3 lysine-79 specific

DOT1-like histone H3 methyltransferase

histone H3 methyltransferase DOT1

histone methyltransferase DOT1L

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15593 Pinometostat Inhibitor 99.99% Phase 2
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15650 SGC0946 Inhibitor 99.68% 否
HY-15227A EPZ004777 hydrochloride Inhibitor 99.46% 否
HY-135128 Dot1L-IN-5 Inhibitor 98.57% 否
HY-135127 Dot1L-IN-4 Inhibitor 99.60% 否
HY-101520A Dot1L-IN-1 TFA Inhibitor 98.56% 否
HY-145813 MU1656 Inhibitor / 否
HY-146724 Dot1L-IN-7 Inhibitor / 否
HY-101520 Dot1L-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dot1l NCBI NCBI:84444
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