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  3. PLA2G2D - phospholipase A2 group IID Gene

PLA2G2D - phospholipase A2 group IID Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酶 A2 组 IID

种属: Homo sapiens

同用名: SPLASH; sPLA2S; PLA2IID; sPLA2-IID

基因 ID: 26279 | 基因类型: protein coding

关于 PLA2G2D

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,111,939-20,119,536 (from NCBI)

This gene has 2 transcripts (splice variants), 118 orthologues and 8 paralogues. Biased expression in lymph node (RPKM 63.3), appendix (RPKM 10.7) and 2 other tissues.

功能概要

该基因编码磷脂酶 A2 家族的一个分泌型成员，存在于 1 号染色体上的相关家族成员簇中。磷脂酶 A2 家族成员水解甘油磷脂的 sn-2 脂肪酸酯键，产生溶血磷脂和游离脂肪酸。该基因可能参与炎症和免疫反应，以及与慢性阻塞性肺病相关的体重减轻。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 11 月]

This gene encodes a secreted member of the Phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

PLA2G2D 基因产物(2)

mRNA Protein Name
NM_001271814.2 NP_001258743.1 group IID secretory phospholipase A2 isoform 2 precursor
NM_012400.4 NP_036532.1 group IID secretory phospholipase A2 isoform 1 precursor

PLA2G2D 蛋白结构

Phospholip_A2_1

Phospholip_A2_1: Phospholipase A2 (22 - 130)

  • 0
  • 100
  • 145 a.a.
蛋白主名 其他名称

group IID secretory phospholipase A2

GIID sPLA2

重组 PLA2G2D 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71653 PLA2G2D Protein, Human (His-SUMO) Q9UNK4 (22I-145C) ≥95%

关联疾病

疾病名称 别名
Gas Gangrene

Myonecrosis

Gas Bacillus Infection

Gas Gangrene Due To Clostridia

Clostridial Myonecrosis

Clostridial Cellulitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10622 PLA2G2D Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLA2G2D RGD RGD:1309862
Canis familiaris PLA2G2D VGNC VGNC:44623
Felis catus PLA2G2D VGNC VGNC:107601
Macaca mulatta PLA2G2D VGNC VGNC:100038
Mus musculus PLA2G2D MGD MGI:1341796
Others PLA2G2D NCBI
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