Abcg2 - ATP binding cassette subfamily G member 2 (Junior blood group) Gene

中文名称：ATP 结合盒亚家族 G 成员 2 (初级血型)

种属: Mus musculus

同用名: MXR; ABCP; BCRP; MXR1; ABC15; Bcrp1

关于 Abcg2

功能概要

由该基因编码的膜相关蛋白包含在 ATP 结合盒 (ABC) 转运蛋白超家族中。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族（ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White）。这种蛋白质是 White 亚家族的成员。或者被称为乳腺癌抗性蛋白，人类蛋白质起着异生素转运蛋白的作用，可能在多药耐药性中起主要作用。这种蛋白质可能作为响应米托蒽醌和蒽环类药物暴露的细胞防御机制。 [RefSeq 提供，2008 年 7 月]

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast Cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]