PLA2G5 - phospholipase A2 group V Gene

中文名称：磷脂酶 A2 组 V

种属: Homo sapiens

同用名: FRFB; GV-PLA2; PLA2-10; hVPLA(2)

关于 PLA2G5

功能概要

该基因是分泌型磷脂酶 A2 家族的成员。它位于 1 号染色体上紧密连锁的分泌性磷脂酶 A2 基因簇中。编码的酶催化膜磷脂水解，生成溶血磷脂和游离脂肪酸，包括花生四烯酸。它优先水解含亚油酰的磷脂酰胆碱底物。这种酶的分泌被认为会诱导邻近细胞的炎症反应。已发现可变剪接的转录本变体，但尚未确定其全长性质。[RefSeq 提供，2008 年 7 月]

This gene is a member of the secretory Phospholipase A2 family. It is located in a tightly-linked cluster of secretory Phospholipase A2 genes on chromosome 1. The encoded Enzyme catalyzes the hydrolysis of membrane Phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this Enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]