2. Gene
  3. ST3GAL4 - ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Gene

ST3GAL4 - ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ST3 β-半乳糖苷 α-2,3-唾液酸转移酶 4

种属: Homo sapiens

同用名: STZ; SAT3; ST-4; CGS23; SIAT4; NANTA3; SIAT4C; ST3GalIV; ST3GalA.2; gal-NAc6S

基因 ID: 6484 | 基因类型: protein coding

关于 ST3GAL4

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,355,686-126,414,638 (from NCBI)

This gene has 26 transcripts (splice variants), 221 orthologues and 14 paralogues. Broad expression in adrenal (RPKM 20.2), ovary (RPKM 18.9) and 23 other tissues.

功能概要

该基因编码糖基转移酶 29 家族的成员，这是一组参与蛋白质糖基化的酶。编码的蛋白质靶向高尔基体膜，但可能会被蛋白水解加工和分泌。该基因产物也可能参与炎症反应中唾液酸 Lewis X 抗原表达的增加。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

ST3GAL4 基因产物(9)

mRNA Protein Name
NM_001254757.2 NP_001241686.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2
NM_001254758.2 NP_001241687.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2
NM_001254759.2 NP_001241688.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 3 precursor
NM_001348396.2 NP_001335325.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4
NM_001348397.2 NP_001335326.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4
NM_001348398.2 NP_001335327.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 5 precursor
NM_001348399.2 NP_001335328.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2
NM_001348400.2 NP_001335329.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 precursor
NM_006278.3 NP_006269.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 precursor

ST3GAL4 蛋白结构

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (83 - 331)

  • 0
  • 100
  • 200
  • 300
  • 333 a.a.
蛋白主名 其他名称

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

N-acetyllactosaminide alpha-2,3-sialyltransferase

重组 ST3GAL4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77849 ST3GAL4 Protein, Human (HEK293, His-HA) Q11206 (E41-F333) ≥95%

关联疾病

疾病名称 别名
Hyperglycemia
Developmental And Epileptic Encephalopathy 15

DEE15

Epileptic Encephalopathy, Early Infantile, 15

Eiee15

Developmental And Epileptic Encephalopathy, 15

Early Infantile Epileptic Encephalopathy 15

Encephalopathy, Epileptic, Early Infantile, Type 15

Early Infantile Epileptic Encephalopathy With Suppression Bursts

X-Linked Infantile Spasm Syndrome
Diabetes Mellitus

Diabetes
Diabetic Neuropathy

Diabetic Neuropathies
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13849 ST3GAL4 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ST3GAL4 VGNC VGNC:77827
Felis catus ST3GAL4 VGNC VGNC:65722
Canis familiaris ST3GAL4 VGNC VGNC:46852
Rattus norvegicus ST3GAL4 RGD RGD:1303068
Mus musculus ST3GAL4 MGD MGI:1316743
Bos taurus ST3GAL4 VGNC VGNC:35333
Others ST3GAL4 NCBI
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