1. Gene
  2. PLA2G4C - phospholipase A2 group IVC Gene

PLA2G4C - phospholipase A2 group IVC Gene

中文名称:磷脂酶 A2 组 IVC

种属: Homo sapiens

同用名: CPLA2-gamma

基因 ID: 8605 | 基因类型: protein coding

关于 PLA2G4C

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,047,846-48,110,817 (from NCBI)

This gene has 24 transcripts (splice variants), 253 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.1), heart (RPKM 5.7) and 23 other tissues.

功能概要

该基因编码的蛋白质是磷脂酶 A2 酶家族的成员,该酶家族可水解甘油磷脂以产生游离脂肪酸和溶血磷脂,这两种物质均作为信号分子产生的前体。所编码的蛋白质已被证明是一种钙非依赖性和膜结合酶。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2009 年 4 月]

This gene encodes a protein which is a member of the Phospholipase A2 Enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound Enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

PLA2G4C 基因产物(3)

mRNA Protein Name
NM_001159322.2 NP_001152794.1 cytosolic phospholipase A2 gamma isoform 2 precursor
NM_001159323.2 NP_001152795.1 cytosolic phospholipase A2 gamma isoform 3
NM_003706.3 NP_003697.2 cytosolic phospholipase A2 gamma isoform 1 precursor

PLA2G4C 蛋白结构

PLA2_B

PLA2_B: Lysophospholipase catalytic domain (44 - 242)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 541 a.a.
蛋白主名 其他名称

cytosolic phospholipase A2 gamma

cytosolic lysophospholipase

关联疾病

疾病名称 别名
Pulmonary Systemic Sclerosis

Lung Disease With Systemic Sclerosis

Lung Involvement In Systemic Sclerosis

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PLA2G4C MGD MGI:1196403
Rattus norvegicus PLA2G4C RGD RGD:1594658