2. Anti-infection Membrane Transporter/Ion Channel
  3. Antibiotic Bacterial Na+/K+ ATPase
  4. Gramicidin S

Gramicidin S  (Synonyms: 短杆菌肽 S; Gramicidin soviet)

目录号: HY-P5712 纯度: 99.19%
COA 产品使用指南 技术支持

Gramicidin S (Gramicidin soviet) 是一种选择性靶向细菌细胞膜的阳离子环肽抗生素，具有抗癌活性。Gramicidin S 还破坏膜完整性和干扰膜蛋白功能发挥抗菌活性。Gramicidin S 通过疏水氨基酸残基插入磷脂双层，特异性结合负电荷膜脂并扰乱膜结构，进而抑制细胞分裂和细胞壁合成，最终引发细菌死亡。Gramicidin S 还抑制离子通道，对 Na+/K+-ATPase，烟草叶质膜 Mg2+/K+-ATPase，大鼠心脏质膜 Ca2+-ATPase 的 IC50 分别为 41 μM，24 μM，3 μM。

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Custom Peptide Synthesis

Gramicidin S

Gramicidin S Chemical Structure

CAS No. : 113-73-5

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Gramicidin S 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na+/K+-ATPase, tobacco leaf plasma membrane Mg2+/K+-ATPase, and rat heart plasma membrane Ca2+-ATPase, respectively[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Erythrocyte EC50
11.7 μM
Compound: GS
Cytotoxicity against human erythrocytes assessed as hemolysis after 4 hrs by twofold dilution assay
Cytotoxicity against human erythrocytes assessed as hemolysis after 4 hrs by twofold dilution assay
[PMID: 19674904]
体外研究
(In Vitro)

在膜蛋白定位实验中，Gramicidin S (1 μM；10 min) 导致枯草芽孢杆菌 (Bacillus subtilis) 的外周膜蛋白 MinD、DivIVA 和 PlsX 发生定位紊乱，其中 PlsX 完全失去膜结合能力[1]。
在细胞活力实验中，Gramicidin S (1 μM；30 min) 显著降低大肠杆菌 (E. coli) 细胞活力，通过破坏细胞膜完整性和诱导脂质相分离，导致约 70% 的细胞死亡[1]。
Gramicidin S 具有杀线虫活性，IC50=0.08 μM (松木线虫 Bursaphelenchus lignicolus)，同时抑制大肠杆菌的 IC50=3.5 μM[1]。
Gramicidin S (1 μg/mL，2 μg/mL；9 h) 可独立于 MreB 细胞骨架诱导流体脂质结构域，导致外周膜蛋白 (如参与细胞壁合成的 MurG) 离域化 (delocalization)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gramicidin S 相关抗体:

Cell Viability Assay[1]

Cell Line: Escherichia coli
Concentration: 1 μM
Incubation Time: 30 min
Result: Significantly reduced cell viability, with a 70% decrease in viable cell count compared to the control group.
Disrupted the bacterial membrane by inserting hydrophobic residues into the phospholipid bilayer, inducing lipid phase separation and fluid membrane microdomain formation, which ultimately led to membrane permeability loss and cell death.
体内研究
(In Vivo)

Gramicidin S (20-200 μg/只/天；腹腔注射；每日 1 次；21 天) 在 ICR 小鼠皮下接种 S180 肉瘤模型中，显著抑制肿瘤生长，高剂量组 (200 μg/只/天) 21 天后肿瘤抑制率达 60% 且小鼠体重无显著下降[3]。
Gramicidin S (20-50 μg/只/天；腹腔注射；每日 1 次；16 天) 在 BALB/c 小鼠皮下接种 Meth A 纤维肉瘤模型中，高剂量组 (50 μg/只/天) 16 天后肿瘤抑制率达 60%，但低剂量组抑制效果较弱[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR mice (8 weeks old,) subcutaneously implanted with Sarcoma 180 (S180)[3]
Dosage: 0 (control), 20 μg/mouse/day, 200 μg/mouse/day (dissolved in ethanol and diluted with Dulbecco's PBS)
Administration: Intraperitoneal injection daily for 21 days starting from day 1 after tumor inoculation
Result: On day 21, the high-dose group (200 μg/mouse/day) showed a 60% tumor growth inhibition rate, with a slight increase in body weight, similar to the control group.
No significant difference in survival rate was observed among groups, with 6/8 mice surviving in both the high-dose and control groups.
分子量

1141.45

Formula

C60H92N12O10
CAS 号
性状

固体

颜色

White to off-white

Sequence

cyclo(Val-Orn-Leu-D-Phe-Pro)2
Sequence Shortening

cyclo(VOLDFP)2
中文名称

短杆菌肽 S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (87.61 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8761 mL 4.3804 mL 8.7608 mL
5 mM 0.1752 mL 0.8761 mL 1.7522 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.19%

COA (301 KB) RP-HPLC (110 KB) MS (215 KB) 元素分析报告 (226 KB)

产品使用指南 (1538 KB)
参考文献

Gramicidin S 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8761 mL 4.3804 mL 8.7608 mL 21.9020 mL
5 mM 0.1752 mL 0.8761 mL 1.7522 mL 4.3804 mL
10 mM 0.0876 mL 0.4380 mL 0.8761 mL 2.1902 mL
15 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4601 mL
20 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0951 mL
25 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8761 mL
30 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL
40 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5475 mL
50 mM 0.0175 mL 0.0876 mL 0.1752 mL 0.4380 mL
60 mM 0.0146 mL 0.0730 mL 0.1460 mL 0.3650 mL
80 mM 0.0110 mL 0.0548 mL 0.1095 mL 0.2738 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gramicidin S113-73-5Gramicidin soviet短杆菌肽 SAntibioticBacterialNa+/K+ ATPaseSodium potassium pumpantimicrobialpeptideantibacterialGram-negativeGram-positiveInhibitorinhibitorinhibit

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