2. Others JAK/STAT Signaling Stem Cell/Wnt Epigenetics Protein Tyrosine Kinase/RTK
  3. JAK Isotope-Labeled Compounds Syk
  4. Gusacitinib-d4

Gusacitinib-d4  (Synonyms: ASN-002-d4)

目录号: HY-103018S
产品使用指南 技术支持

Gusacitinib-d4 (ASN-002-d4) 是氘标记的 Gusacitinib (HY-103018)。Gusacitinib (ASN-002) 是一种口服有效的 SYK/JAK 双激酶抑制剂，对 SYK、JAK1、JAK2、JAK3 和 TYK2 的 IC50 值分别为 5、46、4、11 和 8 nM。Gusacitinib 能够快速显著地抑制与特应性皮炎发病机制相关的关键炎症通路。Gusacitinib 可用于慢性手部湿疹和基底细胞癌等癌症的研究。

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Gusacitinib-d<sub>4</sub>

Gusacitinib-d4 Chemical Structure

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Other Forms of Gusacitinib-d4:

Gusacitinib-d4 相关抗体

Top Publications Citing Use of Products

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JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gusacitinib-d4 (ASN-002-d4) is the deuterium labeled Gusacitinib (HY-103018). Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gusacitinib-d4 相关抗体:
分子量

464.56

Formula

C24H24D4N8O2
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gusacitinib-d4 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gusacitinib-d4ASN-002-d4JAKIsotope-Labeled CompoundsSykJanus kinaseSpleen tyrosine kinaseInhibitorinhibitorinhibit

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