2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor Sigma Receptor
  4. H3R antagonist 6

H3R antagonist 6 (Compounds 3) (H3-2406) 是一种组胺受体 3 (H3R) 拮抗剂，其IC50 为 5.6 nM。经 18F 标记的 H3R antagonist 6 具有较高的放化产率、摩尔活性和中等的脑摄取率，但与 Sigma-1 受体(Sigma-1 receptor) 存在脱靶结合。H3R antagonist 6可用作正电子发射断层扫描 (PET) 成像的放射性配体，用于中枢神经系统 (CNS) 疾病研究。

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H3R antagonist 6

H3R antagonist 6 Chemical Structure

CAS No. : 2183338-59-0

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H3R antagonist 6 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

H3R antagonist 6 (Compounds 3) (H3-2406) is a Histamine receptor 3 (H3R) antagonist with an IC50 of 5.6 nM. H3R antagonist 6 labeled with 18F has high radiochemical yield, molar activity and moderate brain uptake, but with an off-target binding to the Sigma-1 receptor. H3R antagonist 6 can be used as a PET radioligand for positron emission tomography imaging for central nervous system (CNS) disorders research[1].

IC50 & Target[1]

H3 receptor

5.6 nM (IC50)

Sigma 1 Receptor

 

分子量

316.41

Formula

C19H25FN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

H3R antagonist 6 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H3R antagonist 62183338-59-0Histamine ReceptorSigma ReceptorAntagonistH3R18FOff-targetSigma-1 receptorPET radioligandCentral nervous systemCNSInhibitorinhibitorinhibit

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