2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-14

HDAC6-IN-14 是一种高选择性 HDAC6 (HDAC) 抑制剂，IC50 为 42 nM。HDAC6-IN-14 的选择性是 HDAC1/HDAC2/HDAC3/HDAC4 的 100 倍以上。

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HDAC6-IN-14 Chemical Structure

HDAC6-IN-14 Chemical Structure

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HDAC6-IN-14 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-14 is a highly selective HDAC6 (HDAC) inhibitor with an IC50 of 42 nM. HDAC6-IN-14 displays >100-fold selectivity over HDAC1/HDAC2/HDAC3/HDAC4[1].

IC50 & Target[1]

HDAC6

42 nM (IC50)

HDAC1

8.01 μM (IC50)

HDAC2

4.48 μM (IC50)

HDAC3

8.35 μM (IC50)

HDAC4

>10 μM (IC50)

体外研究
(In Vitro)

HDAC6-IN-14 (compound 10p; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells[1].
HDAC6-IN-14 (compound 10p; 6-36 μM; 24 h) treatment induces acetylation of α-tubulin but has no effect on Ac-H3 levels even at concentrations of ≤36 μM in HL60 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-14 相关抗体:

Apoptosis Analysis[1]

Cell Line: HL60 cells
Concentration: 1 μM and 5 μM
Incubation Time: 48 h
Result: Resulted in a significant apoptosis induction.

Western Blot Analysis[1]

Cell Line: HL60 cells
Concentration: 6 μM, 12 μM, 24 μM, 36 μM
Incubation Time: 24 h
Result: Induced acetylation of α-tubulin but had no effect on Ac-H3 levels.
分子量

443.51

Formula

C24H30FN3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-14HDACHistone deacetylasesHDAC6 inhibitorselectiveacetylation of α-tubulinInhibitorinhibitorinhibit

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产品名称：
HDAC6-IN-14
目录号：
HY-151896
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