2. MAPK/ERK Pathway
  3. MAP4K
  4. HPK1-IN-31

HPK1-IN-31(compound 5i) 是一种具有口服活性的造血祖细胞激酶 1 (HPK1) 抑制剂，IC50 值为 0.8 nM。HPK1-IN-31 具有抗肿瘤活性，在免疫研究方面具有巨大的潜力。

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HPK1-IN-31 Chemical Structure

HPK1-IN-31 Chemical Structure

CAS No. : 3003026-16-9

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HPK1-IN-31 相关抗体

Top Publications Citing Use of Products

查看 MAP4K 亚型特异性产品:

查看所有亚型
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunoresearch[1].

体内研究
(In Vivo)

HPK1-IN-31(compound 5i) (p.o., 30 or 100 mpk twice daily, 14 days) inhibits tumour growth in the CT26 tumour-bearing female BALB/c mouse model and the MC38 tumour-bearing female C57BL/6 mouse model, and is followed by a significant effect when combined with anti-PD-1 monotherapy[1].
The pharmacokinetic parameters of HPK1-IN-31(compound 5i)in Mice and Beagles

mice beagles
5i 1 mg/kg (i.v.) 20 mg/kg (i.g.) 1 mg/kg (i.v.) 5 mg/kg (i.g.)
T1/2 (h) 1.3 3.7 8.1 6.2
Tmax (h) - 0.8 - 1.0
Cmax (ng/mL) 1118 2048 1811.2 539.3
AUC(0-inf)(ng*h/mL) 860 8528 3132.2 4094.9
MRT (h) 1.0 3.9 7.3 8.1
CL (mL/min/kg) 19.7 - 5.9 -
F (%) - 49 - 27

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

539.63

Formula

C30H33N7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HPK1-IN-31 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-313003026-16-9MAP4KMAPK Kinase Kinase KinaseHPK1anti-tumourimmunotherapyInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-152257
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