2. Immunology/Inflammation Apoptosis Anti-infection
  3. COX Apoptosis Parasite
  4. Ibuprofen sodium

Ibuprofen sodium  (Synonyms: (±)-Ibuprofen sodium)

目录号: HY-78131C 纯度: 99.98%
COA 产品使用指南

摩尔计算器

Ibuprofen ((±)-Ibuprofen) sodium 是一种具有口服活性的 COX-1 选择性抑制剂，IC50 值为 13 μM。Ibuprofen sodium 抑制细胞增殖、血管生成，并诱导细胞凋亡 (apoptosis)。Ibuprofen sodium 是一种非甾体抗炎试剂和一氧化氮 (NO) 供体。Ibuprofen sodium 可用于疼痛、肿胀、炎症、感染、免疫学、癌症的研究。

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Ibuprofen sodium Chemical Structure

Ibuprofen sodium Chemical Structure

CAS No. : 31121-93-4

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Customer Review

Other Forms of Ibuprofen sodium:

Ibuprofen sodium 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][5][8].

IC50 & Target[1]

COX-1

13 μM (IC50)

COX-2

370 μM (IC50)

体外研究
(In Vitro)

Ibuprofen sodium (24 h) inhibits COX-1 and COX-2 activity with IC50 values of 13 μM and 370 μM[1].
Ibuprofen sodium (500 μM, 48 h) inhibits cell proliferation and angiogenesis, and induces apoptosis in AGS cells (Adenocarcinoma gastric cell line)[2].
Ibuprofen sodium (500 μM, 48 h) downregulates transcription of Akt, VEGF-A, PCNA, Bcl2, OCT3/4 and CD44 genes, but upregulates RNA levels of wild type P53 and Bax genes in AGS cell[2].
Ibuprofen sodium (500 μM, 24 h) restores microtubule reformation, microtubule-dependent intracellular cholesterol transport, and induces extension of microtubules to the cell periphery in both cystic fibrosis (CF) cell models and primary CF nasal epithelial cells[3].
Ibuprofen sodium (500 μM, 24 h) enhances UV-induced cell death in MCF-7 cells and MDA-MB-231 cells by a photosensitization process[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ibuprofen sodium 相关抗体:

Cell Viability Assay[2]

Cell Line: AGS cells
Concentration: 100-1000 μM
Incubation Time: 24 h, 48 h
Result: Inhibited AGS cell viability with IC50 values of 630 μM (trypan blue staining, 24 h), 456 μM (neutral red assay, 24 h), 549 μM (trypan blue staining , 48 h) and 408 μM (neutral red assay, 48 h).
体内研究
(In Vivo)

Ibuprofen sodium (fed in animal feedings, 300 mg/kg, 14 days) reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer[5].
Ibuprofen sodium (subcutaneous injection, 60 mg/kg, every second day for 15 days) reduces the risk of neuropathy in a rat model of chronic Oxaliplatin‑induced peripheral neuropathy[6].
Ibuprofen sodium (oral administration, 20 mg/kg, every 12 hours, 5 doses total) decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise[7].
Ibuprofen sodium (oral administration, 35 mg/kg, twice daily) attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection[8].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum)[5]
Dosage: 300 mg/kg, daily for 14 days
Administration: Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly)
Result: Suppresed tumor growth, reduced presence of immature monocytes and increased numbers of T cells.
Enhanced Th1 associated cytokines as well as promoted tumor border accumulation of T cells.
Animal Model: Oxaliplatin‑induced peripheral neuropathy[6]
Dosage: 60 mg/kg, every second day for 15 days
Administration: Subcutaneous injection
Result: Lowered sensory nerve conduction velocity (SNCV).
Clinical Trial
分子量

228.26

Formula

C13H17NaO2
CAS 号
性状

固体

颜色

White to off-white

中文名称

布洛芬钠盐；布洛芬钠盐；异丁苯丙酸钠盐；异丁洛芬钠盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 100 mg/mL (438.10 mM)

DMSO 中的溶解度 : 20.83 mg/mL (91.26 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3810 mL 21.9048 mL 43.8097 mL
5 mM 0.8762 mL 4.3810 mL 8.7619 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.98%

COA (189 KB) HNMR (253 KB) LCMS (88 KB)

产品使用指南 (1538 KB)
参考文献

Ibuprofen sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.3810 mL 21.9048 mL 43.8097 mL 109.5242 mL
5 mM 0.8762 mL 4.3810 mL 8.7619 mL 21.9048 mL
10 mM 0.4381 mL 2.1905 mL 4.3810 mL 10.9524 mL
15 mM 0.2921 mL 1.4603 mL 2.9206 mL 7.3016 mL
20 mM 0.2190 mL 1.0952 mL 2.1905 mL 5.4762 mL
25 mM 0.1752 mL 0.8762 mL 1.7524 mL 4.3810 mL
30 mM 0.1460 mL 0.7302 mL 1.4603 mL 3.6508 mL
40 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.7381 mL
50 mM 0.0876 mL 0.4381 mL 0.8762 mL 2.1905 mL
60 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8254 mL
80 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3691 mL
H2O 100 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0952 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ibuprofen31121-93-4(±)-Ibuprofen布洛芬钠盐异丁苯丙酸钠盐异丁洛芬钠盐COXApoptosisParasiteCyclooxygenaseAngiogenesisinflammationAGSgastric canceranti-tumoranti-cancermicrotubulecystic fibrosisphotosensitivitybreast cancerT cellstumor microenvironmentNeuroprotectionInhibitorinhibitorinhibit

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