1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Ipsapirone

Ipsapirone (Synonyms: TVX Q 7821 free base)

目录号: HY-19686
产品使用指南

Ipsapirone (TVX Q 7821),是具有抗焦虑活性的化合物,是 5-HT1A 受体的部分激动剂,也表现出 5-HT1A 受体的拮抗作用,并且只在高剂量时,对 5-HT2 和α1 肾上腺素能表现出抑制作用。

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Ipsapirone Chemical Structure

Ipsapirone Chemical Structure

CAS No. : 95847-70-4

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Description

Ipsapirone (TVX Q 7821), an anxiolytic compound and a 5-HT1A receptor partial agonist, also exhibits 5-HT1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the α1-adrenergic function[1][2].

IC50 & Target[1][2]

5-HT1A Receptor

 

In Vivo

Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats[1].
Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃[1].

Animal Model: Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g)[1].
Dosage: 5 and 10 mg/kg.
Administration: IP 30 min before 8-OH-DPAT and 5-MeODMT injections.
Result: Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.).
Molecular Weight

401.48

Formula

C₁₉H₂₃N₅O₃S

CAS No.

95847-70-4

SMILES

O=C(C1=C2C=CC=C1)N(CCCCN3CCN(C4=NC=CC=N4)CC3)S2(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

IpsapironeTVX Q 7821TVX Q7821TVX Q-78215-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorGeneralizedanxietydisordermajordepressiveInhibitorinhibitorinhibit

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产品名称:
Ipsapirone
目录号:
HY-19686
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