2. Immunology/Inflammation
  3. Interleukin Related
  4. Ivuxolimab

Ivuxolimab  (Synonyms: 艾沃利单抗)

目录号: HY-P99159 纯度: 99.90%
COA 技术支持

Ivuxolimab 是一种靶向 OX40 (CD134) 的全人源 IgG2 激动剂，选择性结合激活的 CD4+ 和 CD8+ T 细胞表面的 OX40 受体，不诱导抗体依赖的细胞毒性作用。Ivuxolimab 可促进 T 细胞增殖、生存和细胞因子 (如 IFN-γ、IL-2) 分泌，抑制调节性 T 细胞功能，增强抗肿瘤免疫反应。Ivuxolimab 可用于黑色素瘤、肝细胞癌、头颈部鳞状细胞癌等研究。

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CAS No. : 2128729-41-7

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥10500
In-stock
10 mg ￥16500
In-stock
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100 mg   询价  

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Ivuxolimab 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ivuxolimab is a fully human IgG2 agonist targeting OX40 (CD134), which selectively binds to the OX40 receptor on the surface of activated CD4+ and CD8+ T cells without inducing antibody-dependent cytotoxicity. Ivuxolimab can promote T cell proliferation, survival and cytokine (such as IFN-γ, IL-2) secretion, inhibit regulatory T cell function, and enhance anti-tumor immune response. Ivuxolimab can be used in the study of melanoma, hepatocellular carcinoma, head and neck squamous cell carcinoma, etc[1][2][3].

同型

Human IgG2 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

IL-2

 

体外研究
(In Vitro)

Ivuxolimab (0.02-2 μg/mL；6 d) 在原代 CD4+ T 细胞增殖实验中可显著促进经抗 CD3/CD28 刺激的 T 细胞增殖，且双表位抗体 (如 11D4-OX.F2) 较单表位抗体活性更强[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ivuxolimab 相关抗体:

Cell Viability Assay[2]

Cell Line: Primary human CD4+ T cells
Concentration: 0.02, 0.2, 2 μg/mL
Incubation Time: 6 days
Result: Result: Induced robust T-cell proliferation, measured by carboxyfluorescein diacetate succinimidyl ester (CFSE) dilution.
体内研究
(In Vivo)

Ivuxolimab ((11D4-OX.F2)) (10 mg/kg；静脉注射；每周 2 次；3 周) 显著抑制小鼠 CT26 荷瘤模型的肿瘤生长，不引起明显体重下降[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice (6-8 weeks old, 18-20 g) with subcutaneous CT26 tumor xenografts[2]
Dosage: 10 mg/kg Ivuxolimab-derived biepitopic antibody (11D4-OX.F2)
Administration: Intravenous injection twice weekly for 3 weeks, starting 24 hours after tumor cell inoculation
Result: Significantly reduced tumor growth compared to isotype control-treated mice, with no significant change in body weight.
Histological analysis showed increased infiltration of CD8+ T cells and reduced regulatory T cell (FoxP3+) density in tumor tissues, indicating enhanced antitumor immune responses.
Clinical Trial
基因 ID

7293  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

142.72 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

艾沃利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized OX40/TNFRSF4 Protein, Human (HEK293, His, HY-P7394) can bind Ivuxolimab. The EC50 for this effect is 20.45 ng/mL.
纯度 & 产品资料
参考文献

Ivuxolimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ivuxolimab2128729-41-7艾沃利单抗Interleukin RelatedILantitumor activityimmunostimulatory activityInhibitorinhibitorinhibit

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