2. MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. JNK MMP
  4. JNK-IN-24

JNK-IN-24 是一种 JNK 抑制剂也是一种抗转移性癌症剂。JNK-IN-24 可下调 Scrib 敲低诱导的癌组织中 JNK 和 MMP1 的表达。JNK-IN-24 促进 ScribRNAi 肿瘤翼盘表型的恢复。JNK-IN-24 可用于研究多种上皮细胞来源的癌症 。

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JNK-IN-24

JNK-IN-24 Chemical Structure

CAS No. : 2226808-28-0

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JNK-IN-24 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNK-IN-24, a JNK inhibitor, is an anti-metastatic cancer agent. JNK-IN-24 downregulates JNK and MMP1 expression in Scrib knockdown induced cancer tissues. JNK-IN-24 promotes recovery from tumorous wing disc phenotype of ScribRNAi. JNK-IN-24 can be used for the study in various epithelial cell-derived cancers[1].

体内研究
(In Vivo)

JNK-IN-24 (Compound 5 f) (15-1000 μM， 掺入以玉米琼脂为基础的食品培养基中) 在不同剂量范围内对野生型蛹发育无致死性[1]。
JNK-IN-24 (250-1000 μM， 掺入以玉米琼脂为基础的食品培养基中) 可以挽救早期蛹死亡，使其完全分化为羽化前成虫并且促进 Scrib ScribRNAi 肿瘤翼盘表型的恢复[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Knockdown Scrib in wing imaginal discs[1]
Dosage: 250, 1000 μM
Administration: Incorporated into a corn agar-based food medium for 36 h
Result: Exhibited significantly reduced Scrib transcript levels.
Decreased the levels of JNK and MMP1.
Restricted cancer cell migration from across anterior to posterior boundary.
分子量

360.79

Formula

C19H17ClO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNK-IN-24 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-IN-242226808-28-0JNKMMPc-Jun N-terminal kinaseMatrix metalloproteinasesMMP1epithelial cell-derived cancersInhibitorinhibitorinhibit

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