2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRASG12C IN-2

KRASG12C IN-2 (化合物 17) 是一种口服有效的 KRASG12C 抑制剂。KRASG12C IN-2 能有效抑制小鼠体内肿瘤生长。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

KRASG12C IN-2 Chemical Structure

KRASG12C IN-2 Chemical Structure

CAS No. : 2706637-12-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of KRASG12C IN-2:

KRASG12C IN-2 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRASG12C IN-2 (compound 17) is an orally active KRASG12C inhibitor. KRASG12C IN-2 inhibits tumor growth in mice[1].

IC50 & Target

KRASG12C[1].
体外研究
(In Vitro)

KRASG12C IN-2 (0-100 nM;72 h) 抑制 MIA-PA-CA-2细胞 (KRASG12C 突变) 增殖，IC50 值为 0.44 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRASG12C IN-2 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MIA-PA-CA-2 cells (with KRASG12C mutant)
Concentration: 0-100 nM
Incubation Time: 72 h
Result: Exhibited antiproliferation activity (IC50 = 0.44 nM).
体内研究
(In Vivo)

KRASG12C IN-2 (10, 30 mg/kg; p.o.; single daily for 22 days) 抑制小鼠体内肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude Balb/c mice (Subcutaneous transplantation model of Mia PaCa-2 cells)[1].
Dosage: 10, 30 mg/kg
Administration: Oral administration; single daily for 22 days.
Result: Inhibited tumor growth in mice, and the inhibition rates are 93.06% (dosage at 10 mg/kg) and 99.64% (dosage at 30 mg/kg), respectively.
Animal Model: Male SD rats and male CD mice[1].
Dosage: 2.0 mg/kg
Administration: i.v.; single
Result: 1.19 Pharmacokinetic Parameters of KRASG12C IN-2 in Male SD rats and Male CD mice[1].
Male SD rats Male CD mice
IV (2 mg/kg) IV (2 mg/kg)
T1/2 (h) 1.9 1.7
CL (mL/min/kg) 71.5 40.6
Vdss/Vdss, u(L/kg) 10.6/221 3.9/32.3
AUC0-last/AUCu (nM•h) 653/31.3 1297/155.6
Animal Model: Male SD rats and male CD mice[1].
Dosage: 9.8, 10.3 mg/kg
Administration: p.o.; single
Result: 1.19 Pharmacokinetic Parameters of KRASG12C IN-2 in Male SD rats and Male CD mice[1].
Male SD rats Male CD mice
PO (9.8 mg/kg) PO (10.3 mg/kg)
AUC0-last/AUCu (nM•h) 995/47.8 1422/170.6
Tmax (h) 1.5 1.0
Cmax/Cmax, u (nM) 220/10.6 431/51.7
F (%) 30.5% 21.9%
分子量

679.66

Formula

C32H35F6N7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRASG12C IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRASG12C IN-22706637-12-7RasMIA-PA-CA-2 cellscancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
KRASG12C IN-2
目录号：
HY-153262
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z