2. Protein Tyrosine Kinase/RTK
  3. VEGFR PDGFR
  4. Linifanib

Linifanib  (Synonyms: 利尼伐尼; ABT-869; AL-39324)

目录号: HY-50751G
产品使用指南

摩尔计算器

Linifanib (ABT-869) (GMP) 是 GMP 级别的 Linifanib (HY-50751)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Linifanib 是一种高效、口服的 VEGFR 和 PDGFR 家族多靶点抑制剂，对 KDR、FLT1、PDGFRβ、FLT3 的 IC50s 分别为 4、3、66、4 nM。Linifanib (GMP) 可促进由体细胞到 iPSC 的生成和重编程。

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Linifanib Chemical Structure

Linifanib Chemical Structure

CAS No. : 796967-16-3

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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Linifanib 的其他形式现货产品:

Customer Review

Other Forms of Linifanib:

Linifanib 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 PDGFR 亚型特异性产品:

查看所有亚型
PDGFR PDGFRβ PDGFRα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells[1].

IC50 & Target

IC50: 4 nM (KDR), 4 nM (FLT1), 66 nM (PDGFRβ), 3 nM (CSF-1R), 4 nM (FLT3), 14 nM (Kit)[1]
体外研究
(In Vitro)

Linifanib (GMP) (1 μM) 诱导人胚胎成纤维细胞 (HEF) 生成 hCiPS 细胞[1]。
Linifanib (GMP) (1 μM) 诱导 hADSCs 或 hASFs 产生 hCiPS 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Linifanib 相关抗体:
Clinical Trial
分子量

375.40

Formula

C21H18FN5O
CAS 号
中文名称

利尼伐尼 (GMP)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Linifanib 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linifanib (GMP)796967-16-3ABT-869 (GMP) AL-39324 (GMP)利尼伐尼 (GMP)VEGFRPDGFRVascular endothelial growth factor receptorPlatelet-derived growth factor receptorGMPcell therapydifferentiatesomatic celltransdifferentiatehCiPSreprogrammingInhibitorinhibitorinhibit

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