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LQVTDSGLYRCVIYHPP 

目录号: HY-P3400 纯度: 99.55%
COA 产品使用指南

LQVTDSGLYRCVIYHPP (LP17) 是一种髓系细胞表达的触发受体 1 (TREM-1) 抑制肽。LQVTDSGLYRCVIYHPP 显著减轻缺血诱导的梗死和神经元损伤。LQVTDSGLYRCVIYHPP 可进入大脑,阻断 TREM-1。

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LQVTDSGLYRCVIYHPP Chemical Structure

LQVTDSGLYRCVIYHPP Chemical Structure

CAS No. : 887255-16-5

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规格 价格 是否有货 数量
1 mg ¥750
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5 mg ¥1800
In-stock
10 mg ¥3200
In-stock
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LQVTDSGLYRCVIYHPP (LP17) is a triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LQVTDSGLYRCVIYHPP substantially alleviates ischemia-induced infarction and neuronal injury. LQVTDSGLYRCVIYHPP can get access into brain and block TREM-1[1].

IC50 & Target

TREM-1[1]

体外研究
(In Vitro)

LQVTDSGLYRCVIYHPP (LP17) (1 或 10 μM;24 小时) 显著降低再氧合后促炎细胞因子和趋化因子的 mRNA 水平,并显著降低小胶质细胞氧-葡萄糖剥夺 (OGD) 中 IL-1β 和 IL-18 的细胞外蛋白水平模型[1]
LQVTDSGLYRCVIYHPP (LP17) (10 μM;24 小时) 与小胶质细胞 SYK 相互作用[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Primary microglia
Concentration: 1 or 10 μM
Incubation Time: 24 h
Result: Decreased mRNA levels of NLRP3, IL-1β, IL-18, IL-6, CD16, CD32, iNOS, MCP-1, CXCL-1, and CXCL-2 after reoxygenation.

Western Blot Analysis[1]

Cell Line: Primary microglia
Concentration: 10 μM
Incubation Time: 24 h
Result: Suppressed ischemia/reperfusion-induced increments in CARD9, p-p65 in CARD9/NF-κB signaling and NLRP3, ASC, cleaved caspase-1, mature IL-1β, and mature IL-18 in NLRP3/caspase-1 signaling in a microglia oxygen-glucose deprivation (OGD) model.
体内研究
(In Vivo)

LQVTDSGLYRCVIYHPP (LP17) (0.5 或 1 mg/kg;鼻内;每天一次,持续 3 天) 减轻小鼠缺血诱导的梗塞和神经元损伤[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male C57BL/6J mice (20-25 g), mice cerebral ischemia/reperfusion (I/R) model induced by middle cerebral artery occlusion (MCAO)[1]
Dosage: 0.5 mg/kg or 1 mg/kg
Administration: Intranasal administration, once daily for 3 consecutive days after MCAO
Result: Abolished ischemia-induced TREM-1 elevation at 1 mg/kg. Significantly reduced infarct volume by 27.3%, induced a markedly reduction in TUNEL positive cells and FJC positive neurons at 1 mg/kg. Rescued neurological deficits and cognitive dysfunction of MCAO mice. Inhibited microglial M1 polarization and neutrophil infiltration.
分子量

1961.24

Formula

C89H137N23O25S

CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

LQVTDSGLYRCVIYHPP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 25 mg/mL (12.75 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

H2O 中的溶解度 : 5 mg/mL (2.55 mM; 超声助溶; 酸性条件溶解 (HCL 调节,pH≈2))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5099 mL 2.5494 mL 5.0988 mL
5 mM 0.1020 mL 0.5099 mL 1.0198 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.78%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.5099 mL 2.5494 mL 5.0988 mL 12.7470 mL
DMSO 5 mM 0.1020 mL 0.5099 mL 1.0198 mL 2.5494 mL
10 mM 0.0510 mL 0.2549 mL 0.5099 mL 1.2747 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LQVTDSGLYRCVIYHPP
目录号:
HY-P3400
需求量: