2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. LY 541850

LY 541850 是选择性正构 mGlu2 激动剂和 mGlu3 拮抗剂，其 IC50 值分别为 0.161 μM 和 0.038 μM。

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LY 541850 Chemical Structure

LY 541850 Chemical Structure

CAS No. : 852679-76-6

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Other Forms of LY 541850:

LY 541850 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively[1].

IC50 & Target

mGluR2

0.161 μM (IC50)

mGluR3

1.05 μM (IC50)

体内研究
(In Vivo)

LY 541850 (intraperitoneal injection; 10 mg/kg-300 mg/kg; 15 min prior) induces a concentration-dependent inhibition of the TAP evoked fEPSPs in CA1-SLM in 10-16 week old (EC50 42 nM) in CD-1 mice[1].
LY 541850 (intraperitoneal injection; 10 mg/kg-300 mg/kg; 30 min prior) reduces the increased locomotor activity of phencyclidine and amphetamine in a dose-dependent manner in male ICR mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

199.20

Formula

C9H13NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LY 541850 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY 541850852679-76-6LY541850LY-541850mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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产品名称：
LY 541850
目录号：
HY-103551A
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