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  2. Monoamine Oxidase
  3. MAO-IN-M30 dihydrochloride

MAO-IN-M30 dihydrochloride 

目录号: HY-131036
产品使用指南

MAO-IN-M30 dihydrochloride 是一种口服活性,可通过血脑屏障的,脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。

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MAO-IN-M30 dihydrochloride Chemical Structure

MAO-IN-M30 dihydrochloride Chemical Structure

CAS No. : 64821-19-8

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Description

MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease[1][2][3].

IC50 & Target[1]

MAO-A

37 nM (IC50)

MAO-B

57 nM (IC50)

In Vitro

MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone[3].
MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival[4].
MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells[3].

Cell Viability Assay[3]

Cell Line: SH-SY5Y cells
Concentration: 0.25 nM
Incubation Time: 72 hours
Result: Significantly increased cell viability to ∼90% after exposure to Dexamethasone.

Cell Viability Assay[4]

Cell Line: PC12 cells
Concentration: 0-10 μM
Incubation Time: 24 hours
Result: Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.
In Vivo

MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities[6].

Animal Model: Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)[6]
Dosage: 0.5, 2.5 mg/kg
Administration: P.o.; once daily for 14 consecutive days
Result: Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.
Molecular Weight

299.20

Formula

C₁₄H₁₆Cl₂N₂O

CAS No.

64821-19-8

SMILES

OC1=C2N=CC=CC2=C(CN(C)CC#C)C=C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MAO-IN-M30Monoamine OxidaseMAObraincellapoptosisneurorestorativeParkinson'sdiseasefragmentedDNAironchelatorradicalscavengerbrain-permeableInhibitorinhibitorinhibit

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产品名称:
MAO-IN-M30 dihydrochloride
目录号:
HY-131036
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