2. Academic Validation
  3. Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus

Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus

  • J Antibiot (Tokyo). 2000 Nov;53(11):1265-71. doi: 10.7164/antibiotics.53.1265.
S Sakuda 1,  M Ono,  H Ikeda,  T Nakamura,  Y Inagaki,  R Kawachi,  J Nakayama,  A Suzuki,  A Isogai,  H Nagasawa
Affiliations

Affiliation

  • 1 Department of Applied Biological Chemistry, The University of Tokyo, Japan.
PMID: 11213287 DOI: 10.7164/antibiotics.53.1265
Abstract

Blasticidin A, an Antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 microM.

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