2. Academic Validation
  3. [The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine)]

[The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine)]

  • Med Parazitol (Mosk). 1992 Jan-Feb;(1):50-3.
F S Mikhaĭlitsyn,  N P Kozyreva,  S A Rabinovich,  E V Maksakovskaia,  I M Kulikovskaia,  N R Dadasheva,  M N Lebedeva,  A F Bekhli,  N D Lychko,  N A Uvarova
PMID: 1508078
Abstract

Synthesis is described and acute toxicity and antimalaria action is studied in new derivatives of quinoline and benzo(g)quinoline containing a 4-(4-alkylpiperazinyl-1)phenylamine substitute. Only the derivatives of benzo(g)quinoline were found to have a high antimalaria effect and to have advantages over the standard agent chloroquine on their tolerance and protective action. One of the compounds, 4-[4-(4-ethylpiperazinyl-1)phenylamino] benzo(g)quinoline, named QUINOPRAZINE, showed some action against Plasmodium berghei chloroquine--resistant Infection (isolate LN-K65). This agent was elected for further tests.

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