1. Academic Validation
  2. Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii

Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii

  • Z Naturforsch C J Biosci. 2008 May-Jun;63(5-6):383-8. doi: 10.1515/znc-2008-5-612.
Guillermo Schmeda-Hirschmann 1 Emilio Hormazabal Jaime A Rodriguez Cristina Theoduloz
Affiliations

Affiliation

  • 1 Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile. schmeda@utalca.cl
Abstract

Penicillium janczewskii K. M. Zalessky was isolated as an endophytic fungus from the phloem of the Chilean gymnosperm Prumnopitys andina. When grown in liquid yeast extract-malt extract-glucose broth, the fungus produced two main secondary metabolites. The compounds were for the first time isolated from this species and identified by spectroscopic methods as pseurotin A and cycloaspeptide A. This is the first report on the production of cyclic Peptides by endophytic fungi from Chilean gymnosperms. Pseurotin A and cycloaspeptide A presented low cytotoxicity towards human lung fibroblasts with IC50 > or = 1000 microM. Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), respectively.

Figures
Products