2. Academic Validation
  3. Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization

Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization

  • J Med Chem. 2009 Feb 26;52(4):1209-13. doi: 10.1021/jm801333m.
Matteo Piazza 1,  Clara Rossini,  Silvia Della Fiorentina,  Chiara Pozzi,  Francesca Comelli,  Isabella Bettoni,  Paola Fusi,  Barbara Costa,  Francesco Peri
Affiliations

Affiliation

  • 1 Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
PMID: 19161283 DOI: 10.1021/jm801333m
Abstract

New glycolipids and a benzylammonium lipid were rationally designed by varying the chemical structure of a D-glucose-derived hit compound active as lipid A antagonist. We report the synthesis of these compounds, their in vitro activity as lipid A antagonists on HEK cells, and the capacity to inhibit LPS-induced septic shock in vivo. The lack of toxicity and the good in vivo activity suggest the use of some compounds of the panel as hits for antisepsis drug development.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z