2. Academic Validation
  3. Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus

Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus

  • J Virol. 2013 May;87(10):6020-6. doi: 10.1128/JVI.01258-12.
Judith G Alamares-Sapuay 1,  Luis Martinez-Gil,  Silke Stertz,  Matthew S Miller,  Megan L Shaw,  Peter Palese
Affiliations

Affiliation

  • 1 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
PMID: 23487453 DOI: 10.1128/JVI.01258-12
Abstract

We previously performed a small interfering RNA (siRNA) screen and identified serum- and glucocorticoid-regulated kinase 1 (SGK1) as a host factor required for influenza A virus replication. However, the role of SGK1 in the influenza viral life cycle has never been examined. In this study, we demonstrate that SGK1 is required for optimal replication of Influenza Virus, using the SGK1 Inhibitor GSK 650394 and SGK1-specific siRNAs. We also demonstrate that SGK1 is required for viral ribonucleoprotein nuclear export.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z