2. Academic Validation
  3. ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke

ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke

  • J Neural Transm (Vienna). 2014 May;121(5):543-7. doi: 10.1007/s00702-013-1138-2.
Amadeus Gladbach 1,  Janet van Eersel,  Mian Bi,  Yazi D Ke,  Lars M Ittner
Affiliations

Affiliation

  • 1 Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.
PMID: 24337667 DOI: 10.1007/s00702-013-1138-2
Abstract

Ischemic stroke is a leading cause of death. It has previously been shown that blocking activation of extracellular signal-regulated kinase (ERK) with the MEK Inhibitor U0126 mitigates brain damage in rodent models of ischemic stroke. Here we show that the newer MEK Inhibitor PD184161 reduces cell death and altered gene expression in cultured neurons and mice undergoing excitotoxicity, and has similar protective effects in a mouse model of stroke. This further supports ERK inhibition as a potential treatment for stroke.

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