2. Academic Validation
  3. A New Anti-Inflammatory Alkaloid from Roots of Heracleum dissectum

A New Anti-Inflammatory Alkaloid from Roots of Heracleum dissectum

  • Chem Biodivers. 2017 Sep;14(9). doi: 10.1002/cbdv.201700184.
Hai-Long Zhang 1,  Xin-Yuan Wu 2,  Jie Mi 1,  Ya-Jie Peng 1,  Zhi-Gang Wang 3,  Ying Liu 4,  Xiu-Li Wu 2,  Yang Gao 1
Affiliations

Affiliations

  • 1 School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, P. R. China.
  • 2 College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, P. R. China.
  • 3 Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, 150040, P. R. China.
  • 4 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100050, P. R. China.
PMID: 28556437 DOI: 10.1002/cbdv.201700184
Abstract

Using various chromatographic methods, a new piperidinone alkaloid, (3S)-3-{4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenoxy}piperidin-2-one (1), together with 10 known compounds, bergapten (2), xanthotoxol (3), isopimpinellin (4), isobergapten (5), heratomol-6-O-β-d-glucopyranoside (6), scopoletin (7), apterin (8), 3-methoxy-4-β-d-glucopyranosyloxypropiophenone, (praeroside; 9), tachioside (10) and coniferin (11), were isolated from roots of Heracleum dissectum Ledeb. Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. All the isolated compounds were screened for anti-inflammatory activity in vitro. As the results, compound 1 and 8 showed significantly inhibitory activity on nitric oxide production in RAW264.7 cells.

Keywords

Heracleum dissectum; Alkaloids; Anti-inflammation; Ethnic herbs; Structure elucidation.

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