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  3. The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice

The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice

  • J Pharm Pharmacol. 1987 Jan;39(1):57-9. doi: 10.1111/j.2042-7158.1987.tb07165.x.
D J Schrier,  S Moniot,  M I Gluckman,  R B Gilbertsen
PMID: 2880988 DOI: 10.1111/j.2042-7158.1987.tb07165.x
Abstract

A topical preparation of meclofenamic acid (Meclomen) was tested for anti-inflammatory activity in a murine model of carrageenan footpad oedema. The preparation significantly inhibited swelling when applied to the carrageenan-injected paw. Maximum inhibition was observed 4-5 h after carrageenan injection. The topical effects could not be attributed to systemic absorption because the preparation was more inhibitory when applied topically to the carrageenan-injected paw than to a distant site or orally.

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