2. Academic Validation
  3. Chirality from D-guanosine to L-guanosine shapes a stable gel for three-dimensional cell culture

Chirality from D-guanosine to L-guanosine shapes a stable gel for three-dimensional cell culture

  • Chem Commun (Camb). 2021 Dec 3;57(96):12936-12939. doi: 10.1039/c9cc09911e.
Yuqi Du 1,  Tiannan Liu 1,  Fan Tang 1,  Xin Jin 2,  Hang Zhao 1,  Jiang Liu 1,  Xin Zeng 1,  Qianming Chen 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. liujiang@scu.edu.cn.
  • 2 Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing 400016, P. R. China.
PMID: 34734933 DOI: 10.1039/c9cc09911e
Abstract

It is proved that L-guanosine (L-G) as an enantiomer of D-guanosine (D-G) forms more stable gels than D-G, suggesting that alteration of chirality may be a new strategy for improving the lifetime stability of supramolecular hydrogels. Experiments for three-dimensional Cell Culture reveal that the L-G gel is a candidate for the extracellular matrix.

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