2. Academic Validation
  3. Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms

Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms

  • Am J Psychiatry. 1994 Oct;151(10):1499-502. doi: 10.1176/ajp.151.10.1499.
H Wetzel 1,  A Hillert,  G Gründer,  O Benkert
Affiliations

Affiliation

  • 1 Department of Psychiatry, University of Mainz, Germany.
PMID: 7916543 DOI: 10.1176/ajp.151.10.1499
Abstract

Twenty schizophrenic inpatients with either predominantly positive or predominantly negative symptoms were treated with the dopamine autoreceptor agonist roxindole in prospective open clinical trials. There was no antipsychotic effect in the subgroup with positive symptoms, whereas the subgroup with negative symptoms, especially those with the residual type of schizophrenia, showed a moderate but significant 20% reduction in total scores on the Scale for the Assessment of Negative Symptoms.

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