2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Mesdopetam

Mesdopetam  (Synonyms: IRL790)

目录号: HY-109150
产品使用指南

摩尔计算器

Mesdopetam (IRL790) 是一种多巴胺 D3 受体拮抗剂 (Ki=90 nM; IC50=9.8 μM)，具有稳定精神运动的特性。Mesdopetam 用于研究帕金森病的运动和精神并发症。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Mesdopetam hemitartrate 通常具有更好的水溶性和稳定性。

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Mesdopetam Chemical Structure

Mesdopetam Chemical Structure

CAS No. : 1403894-72-3

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Mesdopetam 的其他形式现货产品:

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Mesdopetam 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2].

IC50 & Target[1]

D3 Receptor

 

体内研究
(In Vivo)

Mesdopetam (IRL790) (3.7, 11, 33, or 100 µmol/kg) dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3.7, 11, 33, or 100 µmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl)
Administration: s.c. was administered subcutaneously 4 min before the start of recording
Result: Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.
Clinical Trial
分子量

275.34

Formula

C12H18FNO3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mesdopetam 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mesdopetam1403894-72-3IRL790IRL 790IRL-790Dopamine ReceptorpsychomotorstabilizingpropertiesParkinsondiseaseneurotransmissionInhibitorinhibitorinhibit

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