2. Stem Cell/Wnt
  3. Hippo (MST)
  4. MR24 TFA

MR24 TFA 是 G-5555 (HY-19635) 的衍生物，是一种哺乳动物 STE20 样 (MST) 激酶抑制剂。MR24 TFA 对 MST3/4 的选择性显著高于 MST1/2，其 EC50 值分别为 57 nM 和 583 nM。MR24 (TFA) 可诱导 G1 期细胞周期阻滞。MR24 TFA 可用于癌症研究，例如乳腺癌、肝癌和肺癌。

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MR24 TFA

MR24 TFA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

Other Forms of MR24 TFA:

MR24 TFA 相关抗体

Top Publications Citing Use of Products

查看 Hippo (MST) 亚型特异性产品:

查看所有亚型
MST1 MST2 MST3 MST4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MR24 TFA, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 TFA shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 TFA induces G1 phase cell cycle arrest. MR24 TFA can be used for cancer research, such as breast, liver and lung cancers[1].

IC50 & Target[1]

MST3

57 nM (EC50)

MST4

583 nM (EC50)

体外研究
(In Vitro)

MR24 (compound 24) (1-10 μM，6-72 小时) TFA 对 HCT116 细胞的健康细胞核无显著影响，仅在 10 μM 浓度下导致细胞活力略微下降约 30%[1]。
MR24 (1-10 μM，24-72 小时) TFA 可诱导 HCT116 细胞发生 G1 期细胞周期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MR24 TFA 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 1, 5, and 10 μM
Incubation Time: 24, 48 and 72 h
Result: Increased the fraction of cells in the G1 phase at 10 μM.

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 1 and 10 μM
Incubation Time: 6, 12, 24, 48 and 72 h
Result: Showed no significant effect on the normalized cell count at a concentration of 1 μM.
Resulted in a slight reduction in cell viability by about 30% at a concentration of 10 μM.
Resulted in over 90% healthy nuclei after 24 h at both concentrations used (1 and 10 μM).
分子量

623.02

Formula

C28H30ClF3N6O5
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

MR24 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MR24MR 24MR-24Hippo (MST)MST3/4breast cancerliver cancerlung cancerHippoHCT116Inhibitorinhibitorinhibit

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产品名称：
MR24 TFA
目录号：
HY-157932A
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