2. Neuronal Signaling Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt Cell Cycle/DNA Damage Apoptosis
  3. Trk Receptor Anaplastic lymphoma kinase (ALK) c-Kit EGFR Pim Casein Kinase Checkpoint Kinase (Chk) CDK Apoptosis
  4. Multi-kinase-IN-6

Multi-kinase-IN-6 (compound 10e) 是一种多激酶抑制剂，对 TrkA、ALK2、c-KIT、EGFR、PIM1、CK2α、CHK1 和 CDK2 显示出良好的酶抑制活性。Multi-kinase-IN-6 显示出针对 MCF7、HCT116 和 EKVX 的抗增殖活性，IC50 值分别为 3.36 μM、1.40 μM 和 3.49 μM。Multi-kinase-IN-6 在 MCF7 和 HCT116 细胞中显示细胞周期阻滞在 G1/S 期和 G1 期，具有良好的凋亡 (apoptosis) 效果。

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Multi-kinase-IN-6

Multi-kinase-IN-6 Chemical Structure

CAS No. : 3009081-73-3

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Multi-kinase-IN-6 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

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TrkA TrkB TrkC Trk

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Pim 亚型特异性产品:

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PIM1 PIM2 PIM3

查看 Casein Kinase 亚型特异性产品:

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CK1 CK2

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

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Chk1 Chk2 BUBR1

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect[1].

IC50 & Target[1]

TrkA

0.33 μM (IC50)

CDK2

0.71 μM (IC50)

CK2

0.09 μM (IC50)

PIM1

0.42 μM (IC50)

Chk1

0.15 μM (IC50)

EGFR

0.1 μM (IC50)

c-KIT

0.05 μM (IC50)

ALK2

0.03 μM (IC50)

RET

0.53 μM (IC50)

FLT3

0.34 μM (IC50)

ROS1

0.75 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
EKVX IC50
3.49 μM
Compound: 10e
Antiproliferative activity against human EKVX cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human EKVX cells assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
FHC IC50
32.405 μM
Compound: 10e
Cytotoxicity against human FHCs assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human FHCs assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
HCT-116 IC50
1.4 μM
Compound: 10e
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
MCF-10A IC50
28.745 μM
Compound: 10e
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
MCF7 IC50
3.36 μM
Compound: 10e
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
分子量

321.33

Formula

C17H15N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-kinase-IN-6 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-63009081-73-3Trk ReceptorAnaplastic lymphoma kinase (ALK)c-KitEGFRPimCasein KinaseCheckpoint Kinase (Chk)CDKApoptosisTropomyosin related kinase receptor Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246SCFRCD117Epidermal growth factor receptorErbB-1HER1Pim kinasesCyclin dependent kinaseTrkAALK2c-KITPIM1CK2αCHK1and CDK2Inhibitorinhibitorinhibit

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