2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Naloxonazine dihydrochloride

Naloxonazine dihydrochloride 

目录号: HY-101011 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Naloxonazine dihydrochloride 是一种特异性的 μ-opioid receptor 拮抗剂，IC50 为 5.4 nM。Naloxonazine dihydrochloride 也具有抗利什曼原虫活性。

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Naloxonazine dihydrochloride Chemical Structure

Naloxonazine dihydrochloride Chemical Structure

CAS No. : 880759-65-9

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规格 价格 是否有货 数量
5 mg ￥1900
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Customer Review

Other Forms of Naloxonazine dihydrochloride:

Naloxonazine dihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity[1][2][3].

IC50 & Target

μ Opioid Receptor/MOR

5.4 nM (IC50)

体外研究
(In Vitro)

Naloxonazine is relatively stable in solution[2].
Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI50) of 3.45 μM[3].
Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection[3].
Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Naloxonazine dihydrochloride 相关抗体:
体内研究
(In Vivo)

Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in mice[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice, methamphetamine (METH)-induced locomotor activity model[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, once, 60 min before injecting saline (i.p.) or METH (1 mg/kg, i.p.)
Result: Significantly attenuated the acute METH-induced increase in locomotor activity and phosphor-Thr75 DARPP-32 levels.
分子量

723.69

Formula

C38H44Cl2N4O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 25 mg/mL (34.55 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3818 mL 6.9090 mL 13.8181 mL
5 mM 0.2764 mL 1.3818 mL 2.7636 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (202 KB) 元素分析报告 (219 KB)

产品使用指南 (1538 KB)
参考文献

Naloxonazine dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3818 mL 6.9090 mL 13.8181 mL 34.5452 mL
5 mM 0.2764 mL 1.3818 mL 2.7636 mL 6.9090 mL
10 mM 0.1382 mL 0.6909 mL 1.3818 mL 3.4545 mL
15 mM 0.0921 mL 0.4606 mL 0.9212 mL 2.3030 mL
20 mM 0.0691 mL 0.3455 mL 0.6909 mL 1.7273 mL
25 mM 0.0553 mL 0.2764 mL 0.5527 mL 1.3818 mL
30 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1515 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Naloxonazine880759-65-9Opioid Receptoranti-leishmanialLeishmania donovanirelatively stableInhibitorinhibitorinhibit

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目录号：
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