2. PROTAC Metabolic Enzyme/Protease Autophagy
  3. ATTECs NAMPT Autophagy
  4. NAMPT degrader-1

NAMPT degrader-1 (Compound A3)，是一种自噬体束缚化合物 (ATTEC)，是一种酰胺磷酸核糖转移酶 (NAMPT) 降解剂，IC50 为 0.023 μM。NAMPT degrader-1 通过 autophagy-lysosomal 途径显著诱导 NAMPT 降解，表现出良好的细胞抗肿瘤能力。

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NAMPT degrader-1

NAMPT degrader-1 Chemical Structure

CAS No. : 3011778-39-2

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NAMPT degrader-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency[1].

IC50 & Target

IC50: 0.023 μM (NAMPT)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
0.046 μM
Compound: A3
Antiproliferative activity against human A2780 cells overexpressing NAMPT assessed as cell growth inhibition incubated for 72 hrs
Antiproliferative activity against human A2780 cells overexpressing NAMPT assessed as cell growth inhibition incubated for 72 hrs
[PMID: 35588495]
分子量

1046.78

Formula

C56H68ClN9O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NAMPT degrader-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

NAMPT degrader-13011778-39-2NAMPT degrader1NAMPT degrader 1ATTECsNAMPTAutophagyAutophagosome-tethering compoundsNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorA2780antitumorautophagydegradationInhibitorinhibitorinhibit

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