2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. ODN 24888

ODN 24888 是一种鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN)，对 TLR7/TLR9 介导的信号通路表现出强烈的抑制作用。ODN 24888 损害 IFN-α 水平和 NF-κB 激活，抑制 IL-6 的释放。ODN 24888 参与免疫和炎症应答，可作为疫苗佐剂使用。

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DNA, d(P-thio)(T-C-C-T-G-G-C-c7rGm-G-G-G-A-A-G-T)

ODN 24888 Chemical Structure

CAS No. : 1964506-30-6

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规格 价格 是否有货 数量
1 mg ￥3120
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

ODN 24888 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant[1][2].

IC50 & Target

TLR7

 

TLR9

 

分子量

4904.00

CAS 号
性状

固体

颜色

White to off-white

Sequence

DNA, d(P-thio)(T-C-C-T-G-G-C-c7rGm-G-G-G-A-A-G-T)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

ODN 24888 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 248881964506-30-6ODN24888ODN-24888Toll-like Receptor (TLR)guanine-modifiedINH-ODNIFN-αNF-κBIL6human peripheral blood mononuclear cellsPBMCsInhibitorinhibitorinhibit

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产品名称：
ODN 24888
目录号：
HY-150744
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