1. Epigenetics
  2. Epigenetic Reader Domain
  3. PBRM1-BD2-IN-2

PBRM1-BD2-IN-2 是一种选择性和细胞活性的 PBRM1 溴化域抑制剂。PBRM1-BD2-IN-2 对 PBRM1-BD2 具有结合亲和力和抑制活性, KdIC50 值分别为 9.3 μM 和 1.0 μM。PBRM1-BD2-IN-2 可用于癌症的研究。

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PBRM1-BD2-IN-2 Chemical Structure

PBRM1-BD2-IN-2 Chemical Structure

CAS No. : 2819989-57-4

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1 mg ¥2205
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer[1].

IC50 & Target

Kd: 9.3 μM (PBRM1-BD2), 10.1 μM (PBRM1-BD5), 18.4 μM (SMARCA2B), 69 μM (SMARCA4)[1].
IC50: 1.0 μM (PBRM1-BD2)[1].

体外研究
(In Vitro)

PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line[1].
PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively[1].
PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human prostate cell lines LNCaP, PC3, and RWPE-1
Concentration: 0, 0.1, 1, and 10 μM
Incubation Time: 5 days
Result: Inhibited LNCaP growth at higher concentrations.
分子量

311.14

Formula

C14H9Cl2FN2O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

PBRM1-BD2-IN-2 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PBRM1-BD2-IN-2
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HY-151529
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