Pep2-AVKI 

Pep2-AVKI is a selective peptide inhibitor of the binding of the AMPA receptor subunit (GluR2) at the C-terminal PDZ site to C-kinase (PICK1). Pep2-AVKI does not affect the binding of (AMPA-type glutamate receptor) GluA2 to GRIP or ABP. Pep2-AVKI does not increase the amplitude of AMPA currents. pep2-AVKI can be used to study neurological diseases^[1][2][3][4].

Pep2-AVKI (1 mM) 在小脑星状细胞中选择性地与 PICK 结合，不会改变 (微型兴奋性突触后电流) mEPSC 振幅或频率，但抑制了活性诱导的 (兴奋性突触后电流) EPSC 振幅比的增加^[1]。

Pep2-AVKI (1 mM) 在小脑星状细胞中阻断了含有突触 GluR2 的受体增加^[1]。

Pep2-AVKI 在海马突触体中增加了 AMPA 诱发的 (放射性标记的去甲肾上腺素) [³H]NA 和 (放射性标记的 D-天冬氨酸) [³H]D-ASP，增加 10 μM NMDA/1 μM 甘氨酸/50 μM (S) AMPA 诱导的氚释放，但不会改变 10 μM NMDA/1 μM 甘氨酸诱导的 [³H]D-ASP 释放^[2][3]。

Pep2-AVKI (100 μM) 在突触后神经元中阻断了 (长时程抑制) LTD^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1268.46

C₆₀H₉₃N₁₃O₁₇

1315378-69-8

Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ala-Val-Lys-Ile

YNVYGIEAVKI

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75.  [Content Brief]

  [2]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96.  [Content Brief]

  [3]. Summa M, et al.Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training. Neuropharmacology. 2011 Dec;61(8):1282-90.  [Content Brief]

  [4]. Toyoda H, et al. Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex. J Cell Physiol. 2007 May;211(2):336-43.  [Content Brief]